Epidemiological studies suggest that poor nutrition during pregnancy influences offspring predisposition to experience developmental and psychiatric disorders. Animal studies have shown that maternal undernutrition leads to behavioral impairment, which is linked to alterations in monoaminergic systems and inflammation in the brain. In this study, we focused on the ethanolamine plasmalogen of the brain as a possible contributor to behavioral disturbances observed in offspring exposed to maternal undernutrition. Maternal food or protein restriction between gestational day (GD) 5.5 and GD 10.5 resulted in hyperactivity of rat male adult offspring. Genes related to the phospholipid biosynthesis were found to be activated in the PFC, but not in the NAcc or striatum, in the offspring exposed to prenatal undernutrition. Corresponding to these gene activations, increased ethanolamine plasmalogen (18:0p-22:6) was observed in the PFC using mass spectrometry imaging. A high number of crossings and the long time spent in the center area were observed in the offspring exposed to prenatal undernutrition and were mimicked in adult rats via the intravenous injection of ethanolamine plasmalogen (18:0p-22:6) incorporated into the liposome. Additionally, plasmalogen (18:0p-22:6) increased only in the PFC, and not in the NAcc or striatum. These results suggest that brain plasmalogen is one of the key molecules to control behavior, and its injection using liposome is a potential therapeutic approach for cognitive impairment.
Yoshihito KUBO †a) , Student Member and Yukitoshi SANADA †b) , Fellow SUMMARY Massive multiple-input multiple-output (MIMO) realizes simultaneous transmission to a large number of mobile stations (MSs) and improves frequency utilization efficiency. It is drawing attention as the key technology of the fifth-generation (5G) mobile communication systems. The 5G system is going to be implemented in a high frequency band and massive MIMO beamforming (BF) is applied to compensate propagation loss. In the conventional BF scheme, a transmit beam is selected based on the power of received signals over subcarriers. The signal on a different subcarrier is transmitted with a different directivity. To improve the accuracy of beam selection, this paper proposes a transmit beam selection scheme for massive MIMO. The proposed scheme calculates the expected responses of the signals over the subcarriers based on the relative directivity between a base station (BS) and a MS. The MS calculates the correlation between the received signals and each of the expected response sequences. It then selects the beam with the highest correlation value. It is shown in this paper that the proposed scheme can improve the average signal-to-noise ratio of a received signal by about 1.5dB as compared with that of the power based search scheme. It is also shown that the proposed scheme with limited response coefficients can reduce the computational complexity by a factor of 1/100 while it still increases the average SNR by about 1.0dB.
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