alpha-Tocopherol-transfer protein is a determinant of serum vitamin E concentrations. An abnormality in this protein is a cause of spinocerebellar dysfunction.
The Correlation between the Activity of Tissue Plasminogen Activaor (TPA), Levels of Tissue Plasminogen Activator Inhibitor (PAI-1) Antigen and Serum Lipids in Healthy Subjects
We administered 400 mg of bezafibrate daily to 27 patients with hyperlipidemia for seven moths. Most biochemical parameters remained unchanged, whereas levels of alkaline phosphatase (Al-P)and gamma-glutamyl transpeptidase (y-GTP), which are the hepatobiliary enzymes, were significantly decreased. Blood lipid levels were improved. Al-P levels decreased significantly from the baseline level of 174.5 IU/l to 116.7 IU/l(-26.5%) and compared the changes in serum lipid levels with those in Al-P and ƒÁ-GTPlevels following bezafibrate therapy, we found a slight degree of correlation between changes in y-GTP and triglyceride (T-G) levels, but no correlation at all between the changes of Al-P and totalcholesterol (T-cho), T-G or high density lipoprotein cholesterol (HDL-C). A close correlation was observed between both Al-P and y-GTP (r=0.81, p<0.001). From these results it was suggested that bezafibrate has not only a lipid lowering effect but has a favorable efficacy on the hepatobiliary enzymes.
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