These results indicate that EMD can influence activities of cementoblasts and osteoblasts, and thus may be able to regulate cell activities at a periodontal regenerative site.

Background-Knowledge of the responsiveness of cells within the periodontal region to specific bioactive agents is important for improving regenerative therapies. The aim of this study was to determine the effect of specific growth factors, insulin-like growth factor-I (IGF-I), platelet-derived growth factor-BB (PDGF-BB), and transforming growth factor-β (TGF-β) on cementoblasts in vitro and ex vivo.

ABSTRACT

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