In the groove: In an effort to develop unnatural base pairs, pyridyl nucleoside analogues were synthesized and characterized (see structures). An α‐glycosidic nitrogen atom provides an H‐bond acceptor that does not significantly facilitate pairing with natural nucleobases. However, it forms minor‐groove H‐bonds with water molecules and DNA polymerases that optimize the stability and replication, respectively, of the unnatural base pair.
Für den Aufbau nichtnatürlicher Basenpaare wurden Pyridyl‐Nucleosidanaloga synthetisiert und charakterisiert (siehe Strukturen). Ein α‐glycosidisches N‐Atom wirkt als H‐Brückenacceptor, der die Paarung mit natürlichen Nucleobasen nicht signifikant erleichtert. Es scheint jedoch in der kleinen Furche H‐Brücken mit H2O‐Molekülen und DNA‐Polymerasen zu bilden, die die Stabilität bzw. Replikation des nichtnatürlichen Basenpaars optimieren.
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