Objective
To evaluate the clinical relevance of intraocular pressure (IOP) measured with three different rebound tonometers in an ex vivo analysis and clinical trials in dogs.
Animals and procedures
Ex vivo analysis and clinical trials were performed separately. For the ex vivo analysis, eight enucleated eyes were obtained from four Beagle dogs. IOP values measured with TONOVET® (TV‐IOP), TONOVET‐Plus® (TVP‐IOP), and SW‐500® (SW‐IOP) were compared with manometric IOPs. For clinical trials, each tonometer was evaluated separately, depending on whether TVP‐IOP was higher or lower than 14 mm Hg. One‐way repeatedmeasures analysis of variance, simple linear regression analysis, and Bland‐Altman plots were used for statistical analyses.
Results
In ex vivo analysis, TV‐IOP and TVP‐IOP were not significantly different from manometric IOP. However, SW‐IOP underestimated IOP compared to manometry. Higher discrepancy was observed in TV‐IOP and SW‐IOP with an increase in manometric IOP. In clinical trials, no significant difference was observed between TV‐IOP (9.73 ± 2.92) and TVP‐IOP (11.36 ± 2.23) when TVP‐IOP was lower than 14 mm Hg, but SW‐IOP (8.70 ± 3.03) was significantly lower than TVP‐IOP. TV‐IOP (15.96 ± 6.47) and SW‐IOP (13.09 ± 3.72) were significantly lower than TVP‐IOP (20.08 ± 6.60) when the IOP was higher than 14 mm Hg of TVP‐IOP.
Conclusions
This study demonstrates that the TONOVET® and TONOVET‐Plus® provide a useful approach for ex vivo analysis. In clinical trials, results of TV‐IOP and SW‐IOP were significantly lower than of TVP‐IOP when IOP was higher than 14 mm Hg of TVP‐IOP. The characteristics of rebound tonometers should be considered in clinical settings.
A 13-year-old neutered male Poodle dog was presented with a third eyelid mass in the left eye. The dog had undergone local resection of the mass about a year prior in a private practice. On cytological examination, the mass was diagnosed as adenocarcinoma. Although lung and lymph node metastases were suspected, based upon the computed tomographic results, exenteration was performed to relieve chronic pain and to improve the dog's quality of life. Exenteration carried a good prognosis with no tumor recurrence until 1 year and 10 months after surgery, when local recurrence occurred near the left zygomatic arch.
The purpose of this study was to develop effective dental hygiene chews for cats based on the anatomical features of the dentition and patterns of chewing motion. All cats were volunteered for dental prophylaxis followed by dental impressions using yellow stone and alginate under general anesthesia. Twenty parameters related to dentition were defined in order to compare dental impressions using digital caliper. For the chewing motion study, patterns of chewing motion were identified based on recordings made with a digital camera. Ten cats (4 domestic shorthairs, 2 Russian blues, 1 American shorthair, 1 Persian, 1 Turkish Angora, and 1 Devon Rex) were recruited for the study. The parameters related to teeth and oral size were similar among the studied cats. Chewing motion can be described as more of a guillotine-like motion rather than a crushing motion, with cats chewing 3–7 times before swallowing. The chewing pattern of cats involves shearing for a short period of time followed by immediate swallowing. Therefore, the overall size of the dental hygiene chew could be determined based on the measurement of the oral size for inducing chewing. The surface details of the dental hygiene chew could be designed for prevention and removal of dental calculus and plaque in cats considering the anatomical teeth parameters. Dental hygiene chews customized for cats considering the different anatomical features of their teeth might be effective for oral care.
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