Background and Objective: The unprecedented spread of infectious diseases, such as the COVID-19 pandemic, in psychiatric units has affected the self-efficacy, burnout, and job performances of psychiatric nurses. We conducted a survey to investigate the moderating effect of burnout on the relationship between the self-efficacy and job performances of psychiatric nurses. Materials and Methods: Validated and structured questionnaires were used to collect data from 186 nurses in psychiatric units for COVID-19. The data were analyzed using descriptive statistics, Pearson’s correlation coefficient, and a series of multiple linear regression analyses based on Baron and Kenny’s method using the SPSS 26.0 program. Results: Job performance was positively correlated with self-efficacy (r = 0.75, p < 0.001) but had no significant correlation with burnout (r = −0.11, p = 0.150). Self-efficacy was negatively correlated with burnout (r = −0.22, p = 0.002). Burnout among psychiatric nurses had significant moderating effects on self-efficacy and job performance (β = −0.11, p = 0.024). Conclusions: These findings indicate a need to prevent burnout and to enhance self-efficacy in psychiatric nurses to increase their job performances and serve as a basis for establishing strategies to deploy medical staff in the future.
BackgroundThe influence of childhood adversity on depression is modulated by genetic vulnerability. The apolipoprotein E ε4 (APOE-ε4) allele is a strong genetic risk factor for Alzheimer's disease (AD). Because late-life depressive symptoms could be a part of the preclinical course of AD, the APOE-ε4 allele may contribute to depression in old age.ObjectiveThe aim of this study was to evaluate whether an APOE-ε4 carrier status was associated with depressive symptoms in older adults and to detect the gene–environment interaction between APOE-ε4 status and childhood adversity in relation to depressive symptoms in old age.MethodThe participants consisted of 137 older adults (age range 50–70) without any psychiatric history or clinically significant cognitive impairment. APOE genotypes and measures of childhood adversity and depressive symptoms were obtained.ResultsThere was a significant positive association between adverse childhood experiences (ACE) scores and depressive symptoms (B=0.60; 95% CI=0.26, 0.93 for a 1 score increase in ACE scores; p=0.001). Although APOE-ε4 status per se was not associated with depressive symptoms, there was a significant interaction of the ACE scores with the APOE genotype in relation to depressive symptoms (B=0.78; 95% CI=0.02, 1.55; p=0.044). There was a significantly higher effect of childhood adversity on depressive symptoms in APOE-ε4 carriers than non-carriers (t=2.13, p=0.035).ConclusionsOur results suggest that the APOE-ε4 may modulate the association between childhood adversity and depressive symptoms in older adults. However, more research in a larger sample is needed to gain a better understanding of the relationship between the APOE-ε4, childhood adversity, and depression.
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