] B (n = 6) (−59%, P = 0.0004). A significant negative correlation was observed between IMPA2 mRNA levels and [Ca 2+ ] B in BLCLs from male (P = 0.046), but not female BD-I patients. Sex-dependent differences were also evident in postmortem temporal cortex IMPA2 mRNA levels which, in contrast to BLCLs, were significantly higher in male BD-I subjects compared with male controls (P = 0.025, n = 4/group). Collectively, these observations suggest a potential sex-dependent link between abnormalities in IMPA2 expression and calcium homeostasis in the pathophysiology of BD. Molecular Psychiatry (2001) 6, 678-683.
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