One of the biological functions of lactoferrin is the modulation of the host defense systems, including cytokine production and immune responses. We have tested the effect of lactoferrin on the productions of tumor necrosis factor-␣ and nitric oxide in some cells. Lactoferrin itself did not induce either tumor necrosis factor-␣ production or nitric oxide production, but lipopolysaccharide-stimulated tumor necrosis factor-␣ production of macrophages and monocytes were inhibited by lactoferrin treatment combined with stimulant. The induction of nitric oxide synthesis in stimulated macrophages and vascular smooth muscle cells was not affected by the lactoferrin.
The authors wish to point out that in order to amplify the DNA fragment containing the CA repeat, the reverse complement of the primer called CRYB2-B should be used. The corrected CRYB2-B is:A previously missed G residue results in a shift in reading frame near the carboxy terminus. This shortens the coding region by about 100 amino acyl residues. The correct carboxy-terminal sequence is: EATLALSETTNPMGHM.
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