Spatial modulation of sound velocity below the wavelength scale can introduce strong frequency-dependent acoustic responses in tailored composite materials, regardless the fact that most natural bulk materials have negligible acoustic dispersions. Here, for the first time, we experimentally demonstrate a metamaterial that traps broadband acoustic waves and spatially separates different frequency components, as the result of dispersion and wave velocity control by designed gradient subwavelength structures. The trapping positions can be predicted by the microscopic picture of balanced interplay between the acoustic resonance inside individual apertures and the mutual coupling among them. With the enhanced wave-structure interactions and the tailored frequency responses, such metamaterial allows precise spatial-spectral control of acoustic waves and opens new venue for high performance acoustic wave sensing, filtering, and nondestructive metrology.

Acoustic sensors play an important role in many areas, such as homeland security, navigation, communication, health care and industry. However, the fundamental pressure detection limit hinders the performance of current acoustic sensing technologies. Here, through analytical, numerical and experimental studies, we show that anisotropic acoustic metamaterials can be designed to have strong wave compression effect that renders direct amplification of pressure fields in metamaterials. This enables a sensing mechanism that can help overcome the detection limit of conventional acoustic sensing systems. We further demonstrate a metamaterial-enhanced acoustic sensing system that achieves more than 20 dB signal-to-noise enhancement (over an order of magnitude enhancement in detection limit). With this system, weak acoustic pulse signals overwhelmed by the noise are successfully recovered. This work opens up new vistas for the development of metamaterialbased acoustic sensors with improved performance and functionalities that are highly desirable for many applications.

Dietary flavonoids catechin, epicatechin, eriodictyol, and hesperetin were investigated as substrates and inhibitors of human sulfotransferases (hSULTs). Purified recombinant proteins and human intestine cytosol were used as enzyme sources. hSULT1A1 and hSULT1A3 as well as human intestine cytosol can catalyse the sulfation of the investigated flavonoids. Sulfation of catechin, epicatechin, eriodictyol, and hesperetin by recombinant hSULTs showed substrate inhibition at high flavonoid concentrations. Hesperetin and eriodictyol are potent inhibitors of purified hSULT1A1, hSULT1A3, hSULT1E1, and hSULT2A1. Catechin and epicatechin inhibited hSULT1A1 and hSULT1A3, but not hSULT1E1 and hSULT2A1. The sulfation efficacy and potency of inhibition is related to the C-ring structure of flavonoids. These results suggest that dietary flavonoids may regulate human SULT activity and, therefore, affect the regulation of hormones and neurotransmitters, detoxification of drugs, and the bioactivation of pro-carcinogens and pro-mutagens.

In this paper we explore the existence of electromagnetic surface bound modes on a perfect metal wire milled with arrays of subwavelength grooves. The surface modes are axially symmetric transverse magnetic (TM) waves and have the same polarization state with the dominant propagating surface plasmon polaritons on the real metal wires. The dispersion of the fundamental surface mode has close resemblance with the dispersion of the surface plasmon polaritons. Moreover, we note that for TM polarization this metallic structure can be equivalent to a dielectric coated metal wire with defined geometrical parameters and effective refractive index of the dielectric coating. This metallic structure is expected to have some potential applications in the optical research in microwave or THz region.

We investigate the resonant properties of high quality-factor membrane-based metamaterial resonators functioning in the terahertz regime. A number of factors, including the resonator geometry, dielectric loss, and most importantly the membrane thickness are found to extensively influence the resonance strength and quality factor of the sharp resonance. Further studies on the membrane thickness-dependent-sensitivity for sensing applications reveal that high quality-factor membrane metamaterials with a moderate thickness ranging from 10 to 50 μm are the most promising option towards developing realistic integrated terahertz filters and sensors

We demonstrate a novel miniature multi-parameter sensing device based on a plasmonic interferometer fabricated on a fiber facet in the optical communication wavelength range. This device enables the coupling between surface plasmon resonance and plasmonic interference in the structure, which are the two essential mechanisms for multi-parameter sensing. We experimentally show that these two mechanisms have distinctive responses to temperature and refractive index, rendering the device the capability of simultaneous temperature and refractive index measurement on an ultra-miniature form factor. A high refractive index sensitivity of 220 nm per refractive index unit (RIU) and a high temperature sensitivity of -60 pm/ °C is achieved with our device.

Graphene has been known to possess exceptional mechanical properties, including its extremely high Young’s modulus and atomic layer thickness. Although there are several reported fiber optic pressure sensors using graphene film, a key question that is not well understood is how the suspended graphene film interacts with the backing air cavity and affects the sensor performance. Based on our previous analytical model, we will show that the sensor performance suffers due to the significantly reduced mechanical sensitivity by the backing cavity. To remedy this limitation, we will, through experimental and numerical methods, investigate two approaches to enhance the sensitivity of fiber optic acoustic pressure sensors using graphene film. First, a graphene–silver composite diaphragm is used to enhance the optical sensitivity by increasing the reflectivity. Compared with a sensor with pure graphene diaphragm, graphene–silver composite can enhance the sensitivity by threefold, while the mechanical sensitivity is largely unchanged. Second, a fiber optic sensor is developed with enlarged backing air volume through the gap between an optical fiber and a silica capillary tube. Experimental results show that the mechanical sensitivity is increased by 10× from the case where the gap side space is filled. For both approaches, signal-to-noise ratio (SNR) is improved due to the enhanced sensitivity, and COMSOL Thermoviscous acoustics simulation compares well with the experimental results. This study is expected to not only enhance the understanding of fluid–structural interaction in sensor design but also benefit various applications requiring high-performance miniature acoustic sensors.

A working-point trackable fiber-optic hydrophone with high acoustic resolution is proposed and experimentally demonstrated. The sensor is based on a polydimethylsiloxane (PDMS) cavity molded at the end of a single-mode fiber, acting as a low-finesse Fabry-Perot (FP) interferometer. The working point tracking is achieved by using a low cost white-light interferometric system with a simple tunable FP filter. By real-time adjusting the optical path difference of the FP filter, the sensor working point can be kept at its highest sensitivity point. This helps address the sensor working point drift due to hydrostatic pressure, water absorption, and/or temperature changes. It is demonstrated that the sensor system has a high resolution with a minimum detectable acoustic pressure of 148 Pa and superior stability compared to a system using a tunable laser.