In order to improve the network layer of the Internet of things to improve transmission reliability, save time delay and energy consumption, the Internet of things cooperative communication and intelligent agent technology were studied in this paper. In cooperative communication, a new cooperative communication algorithm KCN (k-cooperative node), and a reliability prediction model are proposed. The k value is determined by the end-to-end reliability. After k cooperative nodes are selected, other nodes enter dormancy. In aggregate traffic allocation, game theory is used to model the traffic equilibrium and end-to-end delay optimization scenarios. In practice, the optimal duty cycle can be calculated, which makes some cooperative nodes enter an idle state to save energy. Under the premise of guaranteeing end-to-end delay, it is shown that the reliability of the proposed KCN algorithm is better than that of the other existing routing protocols. In the aspect of intelligent agent, a directional source grouping algorithm D-MIP is proposed. This algorithm studies the routing problem of multi-agent parallel access to multiple source nodes. A directed source packet multi-agent routing planning algorithm is proposed. The iterative algorithm of each source node is limited to a sector, and the optimal intelligent agent route is obtained by selecting an appropriate angle. Compared with other algorithms, it is shown through a lot of simulated results that energy consumption and time delay has been saved by the proposed D-MIP algorithm.
Because of the increasing incidence of coronary artery disease, the use of cardiovascular stents is gradually increasing. In percutaneous coronary intervention, advantage of bioresorbable stent is that the stent does not remain in the human body after completing the necessary mechanical support to ensure the blood vessel open, and finally degrades into harmless molecules. Compared with bare stents, which require long-term retention in the body, the incidence of restenosis in stent or late stent thrombosis was lower. Current biodegradable stent mainly include polymers, biodegradable stents and metal alloy stent. Magnesium-based stent degradation and its copolymers are used in the application of biological absorbable stents and attract the attention of researchers.
This article is to review the research progress of the sustained-release effect of triple anti-tuberculosis drugs carried by calcium sulfate/poly-amino acid compound in bone tuberculosis lesion, and to investigate the biocompatibility, sustained-release and antituberculosis properties of calcium sulfate/poly-amino acid compound materials from the aspects of tissue engineering modification. Papers from January 2000 to February 2019 are retrieved in PubMed database and Web of Science database. Searching words are “bone tuberculosis, biocompatibility, sustained release, anti-tuberculosis, calcium sulfate/poly-amino acid”. A total number of 26 articles were included. After the artificial sustained release system of calcium sulfate/poly-amino acid containing triple anti-tuberculosis drugs was put into the bone tuberculosis lesion, the anti-tuberculosis drugs could be released slowly and continuously for up to three months according to results of the related papers. This locally sustained release effect is caused by the direct diffusion of anti-tuberculosis drugs from the carriers and the dispersion of drugs caused by the exposure of drug groups between calcium sulfate crystals after the degradation of the artificial material. The drug concentrations of the three antituberculosis drugs in the bone and lumbago major muscle tissues at each detection time point were higher than those in venous blood. Three anti-tuberculosis drugs carried by calcium sulfate/poly-amino acid compound can be simultaneously released and sustained-released into the bone lesion. It is more efficient and faster to kill tuberculosis bacillus than the single-drug slow-release material which was previously studied, and consistent with the principle of using anti-tuberculosis drugs.
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