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Artificial neural networks (ANNs) have now been widely used for industry applications and also played more important roles in fundamental researches. Although most ANN hardware systems are electronically based, optical implementation is particularly attractive because of its intrinsic parallelism and low energy consumption. Here, we propose and demonstrate fullyfunctioned all optical neural networks (AONNs), in which linear operations are programmed by spatial light modulators and Fourier lenses, and optical nonlinear activation functions are realized with electromagnetically induced transparency in laser-cooled atoms. Moreover, all the errors from different optical neurons here are independent, thus the AONN could scale up to a larger system size with final error still maintaining in a similar level of a single neuron. We confirm its capability and feasibility in machine learning by successfully classifying the order and disorder phases of a typical statistic Ising model. The demonstrated AONN scheme can be used to construct various ANNs of different architectures with the intrinsic parallel computation at the speed of light.

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Gut microbiota dysbiosis, associated with insulin resistance, weak intestinal barrier integrity, and inflammation, may also play a role in the development of dietary-induced nonalcoholic fatty liver disease (NAFLD). This study investigates the effects of dietary Lactobacillus plantarum NA136 administration on gut microbiota composition in an insulin-resistant C57BL/6J mouse NAFLD model. Comparison of mice with and without L. plantarum NA136 treatment revealed that L. plantarum NA136 treatment not only relieved insulin resistance but also significantly increased relative proportions of Desulfovibrio, Alistipes, Prevotella, and Enterorhabdus in gut microbiota of NAFLD mice. Meanwhile, L. plantarum NA136 administration also inhibited pathogenic bacterial growth, while promoting growth of probiotics such as Allobaculum, Lactobacillus, and, most markedly, Bifidobacterium. Moreover, L. plantarum NA136 treatment of NAFLD mice improved intestinal barrier integrity and attenuated high-fat and fructose diet (HFD/F)-induced inflammation. These results implicate gut-liver-axis-dependent microbiota modulation as the underlying mechanism for L. plantarum NA136-induced amelioration of NAFLD. Key points • L. plantarum NA136 corrects gut microbiota disorders caused by a high-fat and fructose diet.• L. plantarum NA136 strengthens the intestinal barrier and reduces inflammation in the liver.• L. plantarum NA136 relieves NAFLD by improving the gut-liver axis.