The effect of intraoperative blood transfusion on the immune function and prognosis of hepatocellular carcinoma (HCC) has not been fully investigated. The aim of this study was to evaluate the effects of intraoperative autologous blood transfusion and allogeneic blood transfusion on immune function and prognosis in surgically treated HCC patients. One hundred fourteen primary hepatic carcinoma patients who would undergo selective operations were divided into two groups, 35 patients in the experimental group received intraoperative autologous blood transfusion and 79 patients in the control group received allogeneic blood transfusion. The amount of serum T lymphocyte subsets, natural killer (NK) cells and immunoglobulin before and after operation, as well as the recurrence-free survival (RFS) were compared. Results shown that, there was no significant difference in the level of immunocytes and immunoglobulin between the two groups before treatment ( P > .05). At 1 day after surgery, there were significant differences in T lymphocyte, NK cells and immunoglobulin levels before and after transfusion. CD3+, CD4+, CD4+/CD8+, and NK cells in autologous transfusion group were significantly higher than those in allogeneic transfusion group ( P < .05); the level of IgG, IgM, and IgA in allogeneic transfusion group were significantly lower than those before operation ( P < .05), the level of IgG, IgM, and IgA in autologous transfusion group did not significantly fluctuate, and significantly higher than those of allogeneic transfusion group ( P < .05). At 5 days after surgery, all indexes of autologous transfusion group recovered to the preoperative level, the levels of CD3+, CD4+, CD4+/CD8+, NK cells, IgG, IgM, and IgA were significantly higher than those of allogeneic transfusion group ( P < .05). The follow-up results showed that the RFS of autologous transfusion group was significantly higher than that of allogeneic transfusion group ( P < .05). In conclusion, compared with allogeneic blood transfusion, intraoperative autologous blood transfusion possessed less impact on immune function, it may even improve immune function and RFS in HCC patients after surgery. Therefore, HCC patients should be recommended to receive autologous blood transfusion instead of allogeneic blood transfusion when they need blood transfusion during the perioperative period.
Allergic rhinitis (AR) is a non-infectious inflammatory disease of the nasal mucosa mainly mediated by IgE after the body is exposed to allergens (Guidelines for diagnosis and treatment of allergic rhinitis, 2010), with paroxysmal episodes of frequent sneezing, a large amount of watery nose, nasal congestion, thickening of the nasal mucosa as the main characteristics (Xuting Ye, Shuili Zheng, & Zhihua Wang, 2016), because it can further induce bronchial asthma, allergic conjunctivitis, otitis media, sinusitis, tracheal and bronchitis, pharyngitis and other diseases, which has a great impact on the quality of life of patients (Chun Wang, Lili Jiang, Zhendong Shi, et al., 2019). Sanfu herbal patch, a method of traditional Chinese medicine winter disease summer treatment, can effectively improve individual immunity and reduce the occurrence of winter diseases. At present, studies have found that the traditional Chinese medicine Sanfu herbal patch as a complementary and alternative treatment of allergic rhinitis has significant effects.
Patients with chronic renal insufficiency (CKD) in the uremic stage can suffer various degrees of damage to various organ systems throughout the body, with the nervous system being common and severe. Chronic kidney disease (CKD) complicated with stroke has a high incidence and poor prognosis, which brings a heavy burden to patients and society. Understanding the risk factors of uremic patients complicated with stroke and taking preventive measures as soon as possible is of great significance for controlling the progress of the disease. The risk factors of uremic patients complicated with stroke are complex and diverse. Traditional risk factors include hypertension, diabetes, atrial fibrillation, dyslipidemia, etc. Non traditional risk factors such as genetic susceptibility, uremia, anemia, mineral and bone abnormalities can also promote the occurrence of stroke. In addition, dialysis related risk factors such as insufficient cerebral perfusion, increased arterial stiffness, and increased blood pressure variability can also cause stroke. Therefore, it is important to identify the risk factors of stroke in uremic patients as early as possible and take targeted preventive measures.
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