Duhuang site and Qinghai Lake site are selected to be China Radiation calibration site forRemote Sensing Satellite Sensors (CRCSRSSS) in 1996.We have conducted three field measurement campaigns in 1994,1996 and 1999 and obtained a lot of characteristic data of atmosphere and ground reflectance. The results show that the Dunhuang site has a good homogeneity with a low standard deviation of the reflectance which is less than 2% at VIS -SWIR range in 20x20Km2.The ground reflectance is between 10% and 35% at O.35-2.5um spectral range. Atmosphere measurement have shown that Aerosol optical depth (AOD) at 550nm in two sites is 0. 125 and 0. 18, which are all small and suitable for in-flight calibration atmosphere condition. The result of Junge aerosol parameter indicate aerosol type in Dunhuang is near to desert model and near to continent model in Qinghai Lake. The columnar water vapor is determined by Modified Langley plot approach in 940nm band of sun photometer .The result of it are compared with radiosonde data and different within 10%. The diffuse-to-global irradiance ratio by 0L754 spetroradiometer is used for the irradiance-based calibration method to improve in-flight sensor calibration accuracy.
Introduction: Allergic rhinitis (AR) is a major chronic inflammatory disease of the respiratory tract. A large number of epidemiological investigations have shown that the prevalence of AR is increasing, resulting in a large social burden. Importantly, the impact of air pollution on health is a widespread concern. We aim to evaluate association of air pollution and AR risk. Methods and analysis: This prospective study includes patients undergoing AR. The exclusion criteria will be as follows: Patients with nasal infection, nasal polyps, nasal tumors, mental disorders, and immunodeficiency will be excluded. Air pollution levels of ambient air pollutants including PM2.5, PM10, sulfur dioxide (SO 2 ), nitrogen dioxide (NO 2 ), carbon dioxide (CO), and O 3 , and patient data will be collected. The correlation analysis will be performed in air pollutants and AR risk. Discussion: This study will provide correlation of NO 2 , SO 2 , PM10, and PM2.5 for AR in several aspects, including symptom score, drug score, quality of life score, asthma control score, side effects, and laboratory examination such as nasal function test, serum total immunoglobulin E, and nasal secretion smear.
In order to overcome adaptation deficiency of PHEV power assembly controlling strategy in complicated driving cycle, adaptive matching controlling strategy of driving-cycle fuzzy recognition was presented. The driving cycles of automobiles were classified in 3 types: rural cycle (RC), urban cycle (UC) and expressway cycle (EC). Based on information of automobile speed and acceleration, environment cycle is recognized via fuzzy inference, on those basis, adaptation of power matching model was realized. Moreover, simulation of power matching adaptive controlling strategy designed in this paper was conducted in ADVISOR. The designed controlling strategy and the electric-assisted controlling strategy were compared and analyzed. The results indicated that compared with electric-assisted controlling strategy, power-matching adaptive strategy of PHEV based on driving-cycle fuzzy recognition could further reduce energy consumption and exhaust emission, which proved that the newly designed controlling strategy could adapt driving cycles and enhance intellectualization of full vehicle.
Hypopharyngeal squamous cell carcinoma (HSCC) is a type of the head and neck squamous cell carcinoma (HNSCC), and it tends to have malignant transformation and result in poor prognosis effected by oncogene. Studies have shown that Golgi phosphoprotein 3 (GOLPH3) is highly expressed in HNSCC, which can activate AKT-mTOR signaling pathway. However, the functions of GOLPH3 in HSCC was unclear. Based on the analysis of 520 patients from The Cancer Genome Atlas (TCGA) database, we employed GOLPH3 stable knockdown and overexpression of FaDu cell lines to investigated that function and impact of GOLPH3 on HSCC in vitro and vivo. The functions and pathway of genes that positively related to GOLPH3 via enrichment analysis and western blot. Our results showed that GOLPH3 promotes HSCC cells proliferation, migration and subcutaneous tumor in vivo. We confirmed the positive correlation between GOLPH3 and AKT-mTOR signal activation in vitro. Enrichment analysis indicated that GOLPH3 is critical for HSCC development. Taken together, GOLPH3 promotes tumor cells proliferation and malignancy via AKT-mTOR signal activation, and this mechanism may be a key factor for HSCC tumor malignancy. It may provide an important target for clinical treatment of HSCC.
Background Hypopharyngeal squamous cell carcinoma (HSCC) is a type of the head and neck squamous cell carcinoma (HNSCC), and it tends to have malignant transformation and result in poor prognosis effected by oncogene. Studies have shown that Golgi phosphoprotein 3 (GOLPH3) is highly expressed in HNSCC, which can activate AKT-mTOR signaling pathway. However, the functions of GOLPH3 in HSCC was unclear. Methods Based on the analysis of 520 patients from The Cancer Genome Atlas (TCGA) database, we employed GOLPH3 stable knockdown and overexpression of FaDu cell lines to investigated that function and impact of GOLPH3 on HSCC in vitro and vivo. In addition, we verifying the functions and pathway of genes that positively related to GOLPH3 via enrichment analysis and western blot. Results GOLPH3 promotes HSCC cells proliferation, migration and subcutaneous tumor in vivo. We confirmed the positive correlation between GOLPH3 and AKT-mTOR signal activation in vitro. Enrichment analysis indicated that GOLPH3 is critical for HSCC development.Conclusion GOLPH3 promotes tumor cells proliferation and malignancy via AKT-mTOR signal activation, and this mechanism may be a key factor for HSCC tumor malignancy. Highlight GOLPH and it activating the mTOR pathway is important mechanism for the tumorigenesis and development of HSCC, which may provide an important target for clinical treatment of HSCC.
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