A highly efficient, Iron nitrate/TEMPO-catalyzed approach for the synthesis of quinazolinones has been achieved via a onepot, tandem aerobic oxidative cyclization of primary alcohols with 2-aminobenzamides. This practical reaction tolerates a broad scope of substrates and could afford a variety of desirable products in good to excellent yields with air as the terminal green oxidant. Thus, the present synthetic protocol provides an efficient and concise strategy for the synthesis of quinazolinones.Scheme 1. Examples of synthetic and natural quinazolinones.

No abstract

No abstract

A highly efficient, one-pot Cu(OAc)2/Cs2CO3-catalyzed protocol for the aerobic oxidative synthesis of quinazolinones from readily available benzyl alcohols and 2-aminobenzonitriles with molecular oxygen as the terminal oxidant has been successfully developed.