Directed and elliptic flows of neutrons and light charged particles were measured for the reaction 197 Au+ 197 Au at 400 MeV/nucleon incident energy within the ASY-EOS experimental campaign at the GSI laboratory. The detection system consisted of the Large Area Neutron Detector LAND, combined with parts of the CHIMERA multidetector, of the ALADIN Time-of-flight Wall, and of the Washington-University Microball detector. The latter three arrays were used for the event characterization and reaction-plane reconstruction. In addition, an array of triple telescopes, KRATTA, 2 was used for complementary measurements of the isotopic composition and flows of light charged particles.From the comparison of the elliptic flow ratio of neutrons with respect to charged particles with UrQMD predictions, a value γ = 0.72 ± 0.19 is obtained for the power-law coefficient describing the density dependence of the potential part in the parametrization of the symmetry energy. It represents a new and more stringent constraint for the regime of supra-saturation density and confirms, with a considerably smaller uncertainty, the moderately soft to linear density dependence deduced from the earlier FOPI-LAND data. The densities probed are shown to reach beyond twice saturation.

Simulations by transport codes are indispensable to extract valuable physical information from heavy-ion collisions. In order to understand the origins of discrepancies among different widely used transport codes, we compare 15 such codes under controlled conditions of a system confined to a box with periodic boundary, initialized with Fermi-Dirac distributions at saturation density and temperatures of either 0 or 5 MeV. In such calculations, one is able to check separately the different ingredients of a transport code. In this second publication of the code evaluation project, we only consider the two-body collision term; i.e., we perform cascade calculations. When the Pauli blocking is artificially suppressed, the collision rates are found to be consistent for most codes (to within 1% or better) with analytical results, or completely controlled results of a basic cascade code. PHYSICAL REVIEW C 97, 034625 (2018) to reach that goal, it was necessary to eliminate correlations within the same pair of colliding particles that can be present depending on the adopted collision prescription. In calculations with active Pauli blocking, the blocking probability was found to deviate from the expected reference values. The reason is found in substantial phase-space fluctuations and smearing tied to numerical algorithms and model assumptions in the representation of phase space. This results in the reduction of the blocking probability in most transport codes, so that the simulated system gradually evolves away from the Fermi-Dirac toward a Boltzmann distribution. Since the numerical fluctuations are weaker in the Boltzmann-Uehling-Uhlenbeck codes, the Fermi-Dirac statistics is maintained there for a longer time than in the quantum molecular dynamics codes. As a result of this investigation, we are able to make judgements about the most effective strategies in transport simulations for determining the collision probabilities and the Pauli blocking. Investigation in a similar vein of other ingredients in transport calculations, like the mean-field propagation or the production of nucleon resonances and mesons, will be discussed in the future publications.

Transport simulations are very valuable for extracting physics information from heavy-ion collision experiments. With the emergence of many different transport codes in recent years, it becomes important to estimate their robustness in extracting physics information from experiments. We report on the results of a transport code comparison project. 18 commonly used transport codes were included in this comparison: 9 Boltzmann-Uehling-Uhlenbeck-type codes and 9 Quantum-MolecularDynamics-type codes. These codes have been required to simulate Au+Au collisions using the same physics input for mean fields and for in-medium nucleon-nucleon cross sections, as well as the same initialization set-up, the impact parameter, and other calculational parameters at 100 and 400 AMeV incident energy. Among the codes we compare one-body observables such as rapidity and transverse flow distributions. We also monitor non-observables such as the initialization of the internal states of colliding nuclei and their stability, the collision rates and the Pauli blocking. We find that not completely identical initializations constitute partly for different evolutions. Different strategies to determine the collision probabilities, and to enforce the Pauli blocking, also produce considerably different results. There is a substantial spread in the predictions for the observables, which is much smaller at the higher incident energy. We quantify the uncertainties in the collective flow resulting from the simulation alone as about 30% at 100 AMeV and 13% at 400 AMeV, respectively. We propose further steps within the code comparison project to test the different aspects of transport simulations in a box calculation of infinite nuclear matter. This should, in particular, improve the robustness of transport model predictions at lower incident energies where abundant amounts of data are available.

Neural development involves the expression of ensembles of regulatory genes that control the coordinate and region-specific expression of a host of other genes, resulting in the unique structure, connectivity, and function of each brain region. Although the role of some specific genes in neural development has been studied in detail, we have no global view of the orchestration of spatial and temporal aspects of gene expression across multiple regions of the developing brain. To this end, we used transcriptional profiling to examine expression levels of 9955 genes in the hypothalamus, hippocampus, and frontal cortex across seven stages of postnatal development and up to four stages of prenatal development in individual male rats (six per group). The results reveal dramatic changes across development in Ͼ97% of the neurally expressed genes. They also uncover a surprising degree of regional differentiation occurring after birth and through the first 2 weeks of life. Cluster analysis identifies 20 clusters of transcripts enriched in genes related to particular functions, such as DNA metabolism, nuclear function, synaptic vesicle transport, myelination, and neuropeptide hormone activity. Thus, groups of genes with related functions change in the brain at specific times, possibly marking critical periods for each function. These findings can broadly serve as a backdrop for studying the role of individual genes in neural development. They also underscore the importance of early postnatal life in the rat, which corresponds to late gestation in the human, as a critical late phase of neural organization and differentiation, even in subcortical regions.

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Background: Simulations by transport codes are indispensable for extracting valuable physical information from heavy-ion collisions. Pion observables such as the π − /π + yield ratio are expected to be sensitive to the symmetry energy at high densities.Purpose: To evaluate, understand and reduce the uncertainties in transport-code results originating from different approximations in handling the production of ∆ resonances and pions. Methods:We compare ten transport codes under controlled conditions for a system confined in a box, with periodic boundary conditions, and initialized with nucleons at saturation density and at 60 MeV temperature. The reactions N N ↔ N∆ and ∆ ↔ N π are implemented, but the Pauli blocking and the mean-field potential are deactivated in the present comparison. Thus these are cascade calculations including pions and ∆ resonances. Results are compared to those from the two reference cases of a chemically equilibrated ideal gas mixture and of the rate equation. Results:For the numbers of ∆ and π, deviations from the reference values are observed in many codes, and they depend significantly on the size of the time step. These deviations are tied to different ways in ordering the sequence of reactions, such as collisions and decays, that take place in the same time step. Better agreements with the reference values are seen in the reaction rates and the number ratios among the isospin species of ∆ and π. Both the reaction rates and the number ratios are, however, affected by the correlations between particle positions, which are absent in the Boltzmann equation, but are induced by the way particle scatterings are treated in many of the transport calculations. The uncertainty in the transport-code predictions of the π − /π + ratio, after letting the existing ∆ resonances decay, is found to be within a few percent for the system initialized at n/p = 1.5. Conclusions:The uncertainty in the final π − /π + ratio in this simplified case of particles in a box is sufficiently small so that it does not strongly impact constraining the high-density symmetry energy from heavy-ion collisions. Most of the sources of

Within the newly updated version of the ultrarelativistic quantum molecular dynamics (UrQMD) model, the transverse-velocity dependence of the elliptic flow of free nucleons from 197 Au+ 197 Au collisions at the incident energy 400 MeV/nucleon is studied within different windows of the normalized c.m. rapidity y 0 . It is found that the elliptic flow difference v n 2 -v p 2 and ratio v n 2 /v p 2 of neutrons versus protons are sensitive to the density dependence of the symmetry energy, especially the ratio v n 2 /v p 2 at small transverse velocity in the intermediate rapidity intervals 0.4 < |y 0 | < 0.6. By comparing either transverse-momentum dependent or integrated FOPI/LAND elliptic flow data of nucleons and hydrogen isotopes with calculations using various Skyrme interactions, all exhibiting similar values of isoscalar incompressibility but very different density dependences of the symmetry energy, a moderately soft to linear symmetry energy is extracted, in good agreement with previous UrQMD or Tübingen QMD model calculations but contrasting results obtained with π − /π + yield ratios available in the literature.