A metal-free synthesis of diversified benzimidazoles from N-arylamidines through a phenyliodine(III) diacetate (PIDA) promoted intramolecular direct C(sp(2))-H imidation has been developed. The reaction proceeds smoothly at 0 °C or ambient temperature to provide the desired products in good to excellent yields. The synthesis of 2-alkyl- or 2-alkyl-fused benzimidazoles, which are generally inaccessible by similar Pd- or Cu-catalyzed approaches, can also be achieved.

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Fibromyalgia patients in the milnacipran studies had high levels of baseline fatigue. Patients receiving milnacipran had statistically significant and clinically meaningful reductions in fatigue that were not completely attributable to indirect treatment effects through pain reduction. Evaluating and managing fatigue are an important clinical concern when treating patients with fibromyalgia.

Wushu has been widely used in the rehabilitation of a variety of diseases, but its effect on patients with cerebral apoplexy has not been clearly explained. Under this background, after reducing the difficulty of Wushu actions, the study focuses on the effect of Wushu exercise on cognitive function and motor function of 71 patients with mild cerebral apoplexy by means of clinical control experiment. By comparing the results of EEG mean and variance, and performance on Montreal Cognitive Assessment Scale and Wolf Motor Function Scale between the experimental group and the control group, it's found that Wushu can promote the recovery of cognitive function and motor function of patients. However, the recovery of cognitive and motor functions of patients is not achieved by the recovery of controlling functions of nerve cell in charge of corresponding functions, but by the compensation effect among nerve cells in different regions. The conclusion of this study has important theoretical and practical significance in guiding the rehabilitation treatment of patients with cerebral apoplexy.

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