Objectives:Th preservatives benzalkonium chlorid (BZC) and potassium sorbate (PS) are widely u ed, not only for na al drops, but also for eyedrops and co metics. How ver, ther e have been many case reports that consider lesions such as d ermatitis or conjunctivitis to b e the r esults of irritation induced by BZC or PS. Methods: We evaluated the histological change aft er the long-term administration ofBZC or PS on rat nasa l respiratory mucosa. Forty rats were us d for the BZC group and 40 rats for PS group. Anima ls in ach group were divid d into four subgroups. Th first subgroup received a lowconcentration preservative solution that was commonly u · d for nasal sprays. The second subgroup received a high-concentration preservative solution that was reported to induce d ermatitis in humans. The third and fourth subgroups received a s teroid .mixed pr servntive solution of low and high concentrations, respectively. The control group was administrnt d normal saline. After each group r eceived 1, 2, and 4 we k s of topical administration, the symptomatic and histological changes on H&E stain were obrv d. Results: Sneezing and nasal rubbing with for I gs were observ din almo tall subgroups by the s . venth day of treatm nt. The pr servatives induced nasal I sion , including intraepithelial glandular formation, inflammatory cell infiltra tion, vascular hyp rplasia, and edematous change. The symptomatic and hi tological chang s wea· pronounced with the prolonged duration of administration. Similar r esults w r ob rv d in the ste roid mixed-solution groups. In the PS st roid mixed-olution group, howeve. r, symptom a nd nasal lesions were reduced with the prolonged duration of administration. Conclusion: ItFrom Lhe D pnrtmenL ofOLolnryngology-Hoad nnd Neck Surgery, ollege of M. dicin , Th atholic Univ rsity of Kor a, Seoul , Kor
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