The first KI-catalyzed direct acyloxylation of indolin-3-ones with carboxylic acids has been developed using 30% aq. H2O2 as a green oxidant at room temperature. Moreover, mechanism studies indicated that a radical oxidation process may be involved for this transformation.
A novel and efficient method for the synthesis of nucleophilic 2-monoarylated indole-3-ones via palladium-catalyzed direct C(sp3)–H arylation of indole-3-ones with aryl halides has been developed.
An organocatalytic asymmetric α-sulfenylation of 2-substituted indolin-3-ones with N-(alkylthio or arylthio)succinimides has been developed for the first time using Cinchona-derived squaramide as the catalyst. Various chiral 2,2disubstituted indole-3-ones with S-and N-containing heteroquaternary carbon stereocenters were obtained with up to 98% yield and 99% ee.
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