Bacillus
species have a long history of widespread use in biocontrol and crop growth-promoting fields. Here, we present the genome sequence of the rhizobacterium
B. badius
NBPM-293. The genome sequence will provide valuable information for a better understanding of the mechanism of plant growth promotion.
Two series of novel steroidal[17,16-d]pyrimidines derived from natural epiandrosterone and androsterone were designed and synthesized, and these compounds were screened for their potential anticancer activities. The preliminary bioassay indicated that some of these prepared compounds exhibited significantly good cytotoxic activities against human gastric cancer (SGC-7901), lung cancer (A549), and hepatocellular liver carcinoma (HepG2) cell lines compared with 5-fluorouracil (5-FU), epiandrosterone, and androsterone. Especially the respective pairs from epiandrosterone and androsterone showed significantly different inhibitory activities, and the possible configuration-activity relationships have also been summarized and discussed based on kinase assay and molecular docking, which indicated that the inhibition activities of these steroidal[17,16-d]pyrimidines might obviously be affected by the configuration of the hydroxyl group in the part of the steroidal scaffold.
To study the effect of Asparagus officinalis polysaccharide on the number and activity of erythrocyte complement receptor 1(CD35) in S180 mice. Red blood cells from mice venous blood are labeled by rat anti-mouse CD35 monoclonal antibody and FITC-conjugated goat anti-mouse antibody. Using flow cytometry, we determined the number of CR1. Using microscope, we studied the adherence between erythrocyte immunity and C3b receptor or tumor-cell by RBC-C3bRR and DTER. Comparing the mean value of the number of CR1 on erythrocyte of high and middle groups with control groups, the mean value of the number of CR1, RBC-C3bRR and DTER of Asparagus officinalis polysaccharide groups are increased significantly. Asparagus officinalis polysaccharide can improve the erythrocyte function of S180 mice, which may be one of antitumor mechanisms.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.