We report the first
catalytic, enantioselective reductive bis-functionalization
of common amides, which provides a facile access to a variety of 2,2-disubstituted
3-iminoindolines in good yields and with excellent enantioselectivities.
The reaction conditions are quite mild and can be run on a gram scale.
In this one-pot reaction, three C–C bonds, one ring, and one
nitrogen-containing tetrasubstituted carbon stereocenter are created
in a catalytic enantioselective manner.
During air combat, especially in high angle-of-attack flight, the use of a failure detection, isolation and estimation (FDIE) system to detect control effector damage, and then to reconfigure the control laws and to inform the remaining maneuverability to the pilot, can enhance the overall combat capability. This paper discusses the evaluation of a modified multiple hypothesis FDIE scheme in a high fidelity nonlinear six degree-of-freedom F-16 simulation. It includes examples of detection of horizontal tail failure at an air combat maneuver entry flight condition, and rudder failure while maneuvering at supersonic speed and low altitude. The simulation results indicate that the FDIE can function properly within a fraction of a second. Thus, further control law reconfiguration and positive pilot alert are possible to benefit the F-16's combat capabilities.
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