No abstract

No abstract

The present study investigated the hypoglycemic action of des-aspartate-angiotensin I (DAA-I), a metabolite of angiotensin I, in two animal models of type 2 diabetes. The rationale was based on our earlier studies demonstrating that DAA-I acts on the angiotensin AT(1) receptor and exerts responses opposing those of angiotensin II and on recent reports that curtailment of angiotensin II formation by angiotensin converting enzyme inhibitors and blockade of the AT(1) receptor attenuate hyperglycemia in type 2 diabetics and diabetic animals. Diabetic KKAy mice and GK rats were administered orally (by gavage) one of the following doses of DAA-I: 400, 600, or 800 nmol/kg.d for 4 and 6 wk, respectively. Control diabetic animals were similarly administered water. Blood glucose of each animal was determined fortnightly by oral glucose tolerance test and blood insulin on the last day of treatment. Animals were killed, and the levels of plasma membrane glucose transporter-4 and cytosolic tyrosine-phosphorylated insulin receptor substrate-1 in hind limb skeletal muscles were determined by Western blot in insulin-challenged and nonchallenged animals. Orally administered DAA-I had no effect on blood insulin level but exerted dose-dependent hypoglycemic action in KKAy mice and GK rats after 4 and 6 wk of treatment, respectively. At the maximal effective dose of 600 nmol/kg, insulin induced a significant increase in plasma membrane glucose transporter-4 and cytosolic tyrosine-phosphorylated insulin receptor substrate-1. These findings show that DAA-I is not an insulin secretagogue and exerts hypoglycemic action by attenuating insulin resistance, the first such demonstration indicating that the nonapeptide is involved in glycemic regulation.

No abstract

No abstract

Background: Obesity is associated with development of diabetes. However, it seems that the level of obesity in association with diabetes may differ from country to country. Aim:To compare BMI and waist circumference in diabetic patients between Vietnamese and Taiwanese.Methods: Subjects were found to be diabetes mellitus by the health examination and had not treatment before. They were 163 Vietnamese and 298 Taiwanese. Body weight, height and waist circumference were measured Results: Compared with Taiwanese, the Vietnamese diabetes had significantly lower in BMI (23.1±4.1 vs. 25.9 ± 3.4 kg/m2, p< 0.001), and waist circumference (82.2 ± 10.2 vs. 86.8± 9.4 cm, p< 0.001; respectively). Conclusion:Vietnamese people may develop diabetes at smaller increase of BMI and waist circumference than the increase in these indices to induce diabetes in Taiwanese, thus indicating that the factors of Type 2 DM in Vietnam such as BMI, genetic, dietary and life-style which have inter-correlate complexly. It requires further in-vestigations.