The protective effect of flunarizine against cerebral hypoxia-anoxia was investigated with various experimental models in mice and rats. The effect of flunarizine was compared with those of cinnarizine, verapamil and pentobarbital. The oral treatment of animals with flunarizine resulted in a consistent and long-lasting-protection against cerebral hypoxia-anoxia in all the models examined: Cytotoxic anoxia by KCN injection, hypercapnic anoxia induced by stopping artificial respiration, hypobaric hypoxia and normobaric hypoxia. The minimal effective dose of flunarizine was 1 to 20 mg/kg. The activity of flunarizine was 4 to 30 times as potent as that of cinnarizine and pentobarbital. Verapamil showed little or no protective effect. The mode of action of flunarizine was different from that of pentobarbital, which showed protection at anaesthetizing doses. These results indicate that flunarizine possesses a universal protective effect against cerebral hypoxia-anoxia, through the mechanism involved remains to be clarified. Hence, it is suggested that flunarizine might exert a beneficial effect on oxygen insufficiency of the brain resulting from cerebral ischemia.
Abstract-Effect of KF4939 on activation of phospholipase C and A2 was examined by using rabbit platelets prelabelled with [14C]-arachidonic acid. The results showed that KF4939 inhibited the activation of the two phospholipases, separately.
We investigated a 皿 ethod to sterilize digital clinical thermometers made of acrylonitrile ・ butadiene ・ styrene resin . To evaluate the bactericidal activity of disinfectants , we devised a method using a sterilized polyethylene bag. A clinical thermometer contaminated with bacteria was submerged in solution of d量sinfectant in a polyethylene bag . After varying Period of contact the solution was poured off and replaced with 50 m ♂of SCDLP ・ broth ( Soybean − casein digest broth with lec1thine & polysorbate 80 ) to check fQr surviving bacterla ; number of the survivors was co 岨 ted by the spiral system
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