Poly[9-(2-methacryloyloxyethyl)adenine] and poly [1-(2-methacryloyloxyethyl)thymine] with one pendant cholesteryl moiety at the polymer end (PMEA-Chol, PMETChol) and with two pendant cholesteryl moieties at both polymer ends as terminal groups (PMEA-2Chol, PMET-2Chol) were prepared by radical polymerization of 9-(2-methacryloyl-oxyethyl)adenine (MEA) and 1-(2-methacryloyloxyethyl)thymine (MET) initiated with 4,4 0 -azobis[(3-cholesteryl)-4-cyanopentanoate] in the presence of 2-mercaptoethanol or thiocholesterol as chain transfer reagents, respectively. The copolymers [PNiPAAm-co-PMEA-nChol (n ¼ 1,2)] composed of N-isopropylacrylamide (NiPAAm) and MEA were also prepared in a similar manner. The self-organization of these polymers and copolymers was confirmed by a fluorescence measurement, and then their critical concentrations of micelle formation (CMC) were determined. The mixture of PMEA-2Chol and cholesterol as a lipophilic drug model formed a lamella type of complex with an interplaner spacing of d ¼ 35.3 Å . The hypochromism based on the formation of a 1 : 1 interaction of adenine and thymine moieties was found to appear in the mixed aqueous solution of PMEA-Chol and PMET-Chol. Complementary interactions were also confirmed in the system of PMET-2Chol and adenosine as well as PMEA2Chol and uridine. Cis-dichlorodiammine platinum(II) (CDDP) was bound to PNiPAAm-co-PMEA-Chol through the adenine moiety by ligand substitution atoms of CDDP. The amount of CDDP loaded on the copolymer was found to be 0.143 g g À1 .
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