Isoindole derivatives were synthesized by the palladiumcatalyzed cyclization of (2-alkynyl)phenylketone O-pentafluorobenzoyloximes in the presence of organometallic compounds such as sodium formate and aryl boronic acid.
Synthesis of Isoindole Derivatives by Palladium-Catalyzed Domino Reaction of (2-Alkynyl)phenylketone O-Pentafluorobenzoyloximes. -The importance of the o-phenylene tether is found to be highly important for an efficient cyclization process. -(KITAMURA, M.; MORIYASU, Y.; OKAUCHI, T.; Synlett 2011, 5, 643-646, http://dx.doi.org/10.1055/s-0030-1259556 ; Dep. Appl. Chem., Fac. Eng., Kyushu Inst. Technol., Tobata, Kitakyushu 804, Japan; Eng.) -Mais 28-109
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