Economic development in Indonesia MSMEs has an important role because the majority of Indonesia's population lives from MSME activities both in the traditional and modern sector. MSME in Central Java is also quite good. However, MSMEs in Central Java also experienced an increase in competitiveness, especially with similar businesses. Therefore, entrepreneurs are required to be able to innovate and dare to explore the resources it has for its business can continue to grow and survive amid the competition. In this study, the authors explain the condition of competitiveness of SMEs in the Kudus Regency is the business of embroidery which from year to year always decreased. Based on the result of the theoretical study directing this study developed a model with five research variables covering entrepreneurial orientation, business environment adaptability, internal resources of company, competitive advantage, and company performance. The results of the analysis show that the entrepreneurship orientation does not positively affect the competitive advantage. The adaptability of the business environment positively affects the competitive advantage. Internal resources of the company positively influence the competitive advantage. Entrepreneurship orientation positively affects the company's performance. Internal resources of the company positively affect the company's performance. Competitive advantage positively affects the company's performance.
Introduction: Phenytoin is reported to heal the enterocutaneous fistula. Meanwhile, vitamin C is known to improve wound healing. The comparison of phenytoin and vitamin C in the treatment of enterocutaneous fistula is never reported.
Methods: A randomized controlled trial with a post-test-only group design using artificial enterocutaneous fistula Ratus Norvegicus male Wistar rats were reported. Rats were divided into four groups randomly, namely, Control (K), Treatment 1: combined phenytoin and vitamin C (P1), Treatment 2: phenytoin (P2), and Treatment 3: vitamin C (P3). Variables under study were a number of fibroblast and angiogenesis. One Way Anova test, followed by the Post-Hoc Test, was used to test the difference among and between groups.
Results: The mean value of fibroblasts in groups K (501.86 ± 107.10), P1 (861.53 ± 25.99), P2 (719.93 ± 24.61), P3 (781.46 ± 28.23). The mean value of angiogenesis in groups K (18.63 ± 4.24), P1 (48.86 ± 10.23), P2 (26.26 ± 1.64), P3 (31.96 ± 2.97). The Post-Hoc test showed that were significant differences in the number of fibroblasts and angiogenesis from the group given a combination of oral phenytoin and vitamin C therapy compared to the group given oral phenytoin, vitamin C, and control (p <0.05).
Conclusion: A combination of oral phenytoin and vitamin C therapy increased the number of fibroblasts and angiogenesis of enterocutaneous fistula in Wistar rats, better than single.
The objectives of this paper is to investigate factors that affecting SMEs performance. Particularly, our study examined the effect of entrepreneurial orientation, adaptability to external environment, and competitive advantage to SMEs performance. We also test the effect of entrepreneurial orientation and adaptability to external environment on SMEs competitive advantage. Results of structural equation modeling on 100 SMEs in Semarang, Central Java, Indonesia, suggested that entrepreneurial orientation and competitive advantage has a positive effect on SMEs business performance. However, our prediction that adaptability to external environment positively affect SMEs performance was not supported. Furthermore, our study also found that entrepreneurial orientation and adaptability to external environment positively affect SMEs competitive advantage.
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