Latar belakang: Kebisingan merupakan bunyi yang memiliki intensitas di atas batas normal dan dapat mengganggu kesehatan pada orang yang terpapar. Paparan kebisingan terjadi dalam proses produksi pada industri pabrik kayu, sehingga pekerja menjadi pihak utama yang terdampak. Dampak yang terjadi utamanya pada sistem kardiovaskular. Penelitian ini bertujuan untuk menganalisis pengaruh kebisingan terhadap tekanan darah dan denyut nadi pada pekerja pabrik kayu PT. Muroco Jember.   Metode: Penelitian ini berjenis analitik observasional dengan desain penelitian cross sectional. Responden penelitian berjumlah 24 orang yang diambil dengan teknik total sampling. Pengukuran kebisingan menggunakan alat sound level meter. Pengumpulan data karakteristik pekerja menggunakan kuesioner. Responden penelitian diukur sebelum dan setelah bekerja, dengan menggunakan sphygmomanometer air raksa untuk tekanan darah dan penghitungan manual denyut nadi pada arteri brachialis. Analisis data menggunakan uji komparasi paired t-test pada level signifikansi 5%.  Hasil: Intensitas kebisingan dari 4 sektor kerja menunjukkan hasil yang beragam. Intensitas kebisingan terendah pada sektor produksi A yaitu 82,9 dB(A), sedangkan tertinggi pada sektor sawmill B yaitu 98,1 dB(A). Sebagian besar responden (66,7%) berusia 29-40 tahun dengan masa kerja responden (62,5%) kurang dari 2 tahun. Sebanyak 91,7% responden tidak memakai APT pada saat bekerja. Berdasarkan uji komparasi paired t-test, didapatkan pengaruh paparan kebisingan akut antara sebelum dan setelah bekerja terhadap tekanan darah sistolik (p= <0,001), diastolik (p=0,049), dan denyut nadi (p=0,020).Simpulan: Terdapat peningkatan yang signifikan terhadap tekanan darah sistolik, diastolik, denyut nadi antara sebelum dan setelah bekerja dalam paparan kebisingan akut pada pekerja pabrik kayu PT. Muroco Jember. Diperlukan penelitian dengan mengendalikan variabel lain yang mengganggu untuk kesempurnaan penelitian selanjutnya. ABSTRACT Title: The Effect of Noise on Blood Pressure and Pulse Rate in Workers at PT. Muroco Jember Wood FactoryBackground: Noise is a sound that has an intensity above the normal limit and may interfere with the health of the exposed person. Exposure to noise often occurs in the production process at the wood processing factory, so that workers become the main person affected. The impact mainly occurs in cardiovascular system. This study aims to analyze the effect of noise on blood pressure and pulse rate in workers at PT. Muroco Jember wood factory.Method: This is an observational analytic research with cross sectional design. The respondents amounted to 24 people taken with total sampling technique. The measurement of noise intensity was using sound level meter. Data collecting of worker characteristics was using questionnaires. Respondents were measured before and after work, using a mercury sphygmomanometer for blood pressure and manual palpation of pulse rate in the brachial artery. Data was analyzed with paired t-test comparative at 5% significance level.Result: The noise intensity of 4 sectors of the factory showed diverse results. The lowest noise intensity is in production sector A, 82.9 dB (A), while the highest is in sawmill B sector, 98.1 dB (A). Most of the respondents (66.7%) were 29-40 years old with respondents working period (62.5%) were less than 2 years. As many as 91.7% of respondents did not use ear protection device while working. Based on paired t-test, there was an effect of acute exposure between before and after working on systolic blood pressure (p < 0,001), diastolic (p = 0.049), and pulse rate (p = 0.020)Conclusion: There was a significant increase in systolic, diastolic blood pressure, and pulse rate between before and after work in an acute noise exposure in worker at PT. Muroco Jember wood factory. Further research is required by controlling other disturbing variables for a better research.

Tuberkulosis (TB) is a infectious disease caused by t Mycobacterium Tuberculosis. Indonesia is the second country with highest number of TB cases in the world after India. Medication adherence is essential for successful TB treatment. One of the factors that can influence someone adherence to TB treatment is knowledge and attitude. This study aimed to know the correlation between knowledge and attitude towards the adherence of medication in tuberkulosis pulmonary patient on continuation phase in umbulsari jember. This study was an obsevational analytic using cross sectional with total sample technique method. Data were obtained through questionnaire (knowledge questionnaire, HRHS, and MMAS-8) then analyzed with Spearman correlation test (p= <0,05). The results showed a significant  between compliance with knowledge at the level of know with the value of p = 0.041. While the results of the correlation of compliance with knowledge at the level of understanding and application and between attitudes and compliance obtained results not signifikan.

Insulin resistance is a condition in which target organs fail to respond normally to insulin. Cassava contains 9,69 percent starch that resist to digestive enzyme in intestine and has been shown to increase insulin sensitivity and enhance β cell function. The aim of this study was to analyze the difference effect of native cassava starch and cassava resistant starch consumption on insulin resistance and β cell function indexes. This study was quasy experimental research with post-test only control group design using 16 male wistar strain rats divided into four groups: K1 (normal rats with standard diet), K2 (diabetic rats with standard diet), P1 (diabetic rats with native cassava starch diet) and P2 (diabetic rats with cassava resistant starch diet). The rats were fed with high fat diet and injected with low-dose streptozotocin to mimic the patogenesis of type 2 diabetes. The rats were then fed with assigned diet for 28 days. The data collection was obtained from laboratory examination of fasting plasma glucose and fasting plasma insulin to determine HOMA-IR and HOMA-B indexes. Post Hoc analysis showed no difference in both indexes between native cassava starch and cassava resistant starch fed groups (p>0,05).

Stage V chronic kidney disease (CKD) patients need renal replacement therapy. Hemodialysis is main choice for renal replacement therapy and correlates with changes of left ventricular function. Left ventricular diastolic function is one parameter of left ventricular function. The aim of this study was to analyze the effect of hemodialysis towards left ventricular diastolic function in stage V CKD patients at RSD dr. Soebandi Jember. This study included 30 patients (17 female, age 48,20±8,02 years) and underwent echocardiography 30 min before and after a hemodialysis session. Sample characteristics were divided into sex, age, duration of hemodialysis, blood pressure before and after hemodialysis. Diastolic function was measured with E/E’ ratio. Diastolic function criteria of 16 samples (53,5%) were normal (E/E’ ratio <10) after doing a hemodialysis session. Mean ratio E/E’ was significantly reduced (13,09±4,55 vs 11,6±5,04,  p<0,05). In conclusion, hemodialysis could increase left ventricular diastolic function in stage V CKD patients at RSD dr. Soebandi Jember.

Latar belakang: Keganasan sinonasal memiliki angka kejadian yang jarang. Adenoid cystic carcinoma (ACC) merupakan tumor ganas tersering kedua di daerah sinonasal, memiliki karakteristik pertumbuhan lambat namun berpotensi metastasis jauh dan rekurensi yang tinggi. Tatalaksana utama penyakit adalah tindakan pembedahan radikal dilanjutkan radioterapi. Pemilihan pendekatan tindakan pembedahan bergantung pada stadium dan lokasi tumor. Prognosis keganasan sinonasal kurang baik, berhubungan dengan tipe histologis tumor, kejadian invasi perineural, perivaskular, dan metastasis jauh, lokasi tumor, usia pasien dan modalitas terapi. Tujuan: Melaporkan satu kasus ACC nasal dengan metastasis regional cervical yang dilakukan tindakan pembedahan dan dilanjutkan radioterapi. Laporan Kasus: Laki-laki, 70 tahun, datang ke klinik THTKL RSUD dr. Saiful Anwar Malang dengan keluhan benjolan di dalam hidung kanan disertai buntu hidung dan riwayat mimisan selama 1 tahun. Pasien dilakukan tindakan pembedahan dengan pendekatan rinotomi lateral menggunakan insisi Moure. Histopatologi jaringan operasi adalah ACC tipe cribiform. Kesimpulan: Tindakan pembedahan dilanjutkan radioterapi masih menjadi baku emas tatalaksanan ACC nasal. Evaluasi berkala jangka panjang harus dilakukan untuk deteksi dini rekurensi lokoregional dan kejadian metastasih jauh pasca tindakan pembedahan dan radioterapi.