An easy atom-economic methodology for the synthesis of tetrahydro-β-carbolino-spiroindolone/ spiroacenapthylene scaffold in one step from tryptamine and isatin have been done via Pictet-Spengler Reaction using lemon juice as a biocatalyst system. The reaction is clean and convenient for the synthesis of spiroindolones. The product was separated via easy chromatographic technique (column/flash) and characterized by 1D NMR (1H, 13 C and DEPT) and HRMS analysis. Bio evaluation against four cancer cell lines (MCF-7, SH-SY5Y, HepG2 and HEK 293) shows good positive indication of activity for 3 g, 3 h and 3 i.
A novel dehydrogenative C‒C bond formation of indoles and N-tosylhydrazones to di(indolyl)methanes (DIMs) has been demonstrated using tris(pentafluorophenyl)borane as catalyst. A wide range of functional groups can be tolerated under...
Green chemistry is an essential part of the chemistry for the organic synthesis and also plays a principal role to save the environment from the harmful and toxic catalysts. Fruit juice catalyzed chemistry is a vital part of green chemistry in which lemon juice play a potential role in a various organic transformations. This review article has been summarized (from 2011-2020) with the application and importance of lemon juice in synthetic organic transformation as well as synthesis of various type of nanoparticles and catalysts. This review article can help the researcher to develop the route for the synthesis of various scaffolds, small molecules, nanoparticles and catalysts under economical and environment friendly condition.
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