In the presence of zinc halide, 2-furyllithium reacts with 2,3-O-isopropylidene-d-glyceraldehyde in a highly stereoselective manner to give the chiral and stereo-defined alcohol, 2,2-dimethyl-4-(2-furyl)hydroxymethyl-1,3-dioxolane, which is further elaborated to afford d-ribulose in three steps.
Die Umsetzung von 2‐Furyllithium (I) mit dem geschützten D‐Glycerinaldehyd (II) verläuft in Gegenwart von Zinkhalogeniden mit einer Stereoselektivität von über 90% unter Bildung von (III), aus dem in drei Stufen D‐Ribulose (IV) hergestellt wird.
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