Periodontitis is an inflammatory oral disease characterized by periodontal pathogenic bacteria as the initiating factor and the destruction of periodontal supporting tissues, that are gingiva, periodontal membrane, and alveolar bone resorption (Kinane, Stathopoulou, & Papapanou, 2017), affecting most of the adults worldwide (Bellentani, 2017; Eke et al., 2015). One of the pathogenic factors of periodontitis is imbalance in the host reactions caused by the appearance and persistence of dysbiotic oral microbiota and other metabolites that cause the overproduction of inflammatory mediators. In addition, periodontitis can induce an imbalance between oxidant and antioxidant agents, ultimately causes the periodontal tissue damages (Hajishengallis, 2015).

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