The clinical oncogenic functions and mechanisms of activating transcription factor 1 (ATF1) in the progression of lung adenocarcinoma have not been completely elucidated. In this study, by employing human lung adenocarcinoma tissues and cells, we detect the correlation of ATF1 expression with the clinicopathological features and prognosis of patients with lung adenocarcinoma and find that ATF1 promotes lung adenocarcinoma cell proliferation and migration by transcriptionally enhancing zinc finger protein 143 (ZNF143) expression. ATF1 and ZNF143 are strongly expressed in lung adenocarcinoma tissues compared with those in the adjacent normal tissues, and high ATF1 and ZNF143 expressions are related to poor disease-free survival of lung adenocarcinoma patients. ATF1 overexpression results in increased proliferation and migration of lung adenocarcinoma cells, whereas knockdown of
ATF1
inhibits cell proliferation and migration. Furthermore, ATF1 transcriptionally regulates the expression of ZNF143, and ATF1 and ZNF143 expressions are positively correlated in lung adenocarcinoma tissues.
ZNF143
knockdown blocks lung adenocarcinoma cell migration, which is mediated by ATF1 upregulation. Hence, this study provides a potential therapeutic candidate for the treatment of lung adenocarcinoma.
We examined the effects of work-related use of information and communication technologies after hours (W_ICTs) by applying the job demands–resources model and person–environment fit theory. Our focus was on the mechanism of the impact of W_ICTs on employees' nonwork time
error admission, the mediating effect of emotional exhaustion, and the moderating effect of person–organization fit. We used experience sampling to make repeated measurements at different time points to obtain the dynamic variation of the variables. There were 55 participants who completed
online questionnaires for 10 consecutive workdays, resulting in 1,035 valid questionnaires for analysis. We found that employees' daily W_ICTs had significant negative effects on their error admission, and significant positive effects on their emotional exhaustion. Further, emotional exhaustion
mediated the relationship between W_ICTs and error admission, and person–organization fit negatively moderated the relationship between emotional exhaustion and error admission.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.