Carrying out green innovation is beneficial for firms to cope with environmental protection pressure and achieve sustainable development. Existing research has paid enough attention to the driver of green innovation, but still does not reveal how green innovation can be conceived and realized. This paper answers the above question from the perspective of international M&As, examines the relationship between exploratory international M&As, exploitative international M&As and green innovation performance, and further probes into how strategic and environmental factors moderate the green innovation effectiveness of exploratory and exploitative M&As. Results indicate that exploratory and exploitative international M&As both are beneficial for green innovation performance, and to maximize green innovation performance, implementing exploratory M&As is more beneficial for firms pursuing high green image and operating in a high green subsidy environment. By contrast, carrying out exploitative M&As is more effective for firms pursuing low green image and operating in a low green subsidy environment. Theoretical and managerial implications are discussed.
Rationale: Increased lipid droplet (LD) formation has been linked to tumor metastasis, stemness, and chemoresistance in various types of cancer. Here, we revealed that LD formation is critical for the adaptation to sorafenib in hepatocellular carcinoma (HCC) cells. We aim to investigate the LD function and its regulatory mechanisms in HCC. Methods:The key proteins responsible for LD formation were screened by both metabolomics and proteomics in sorafenib-resistant HCC cells and further validated by immunoblotting and immunofluorescence staining. Biological function of AKR1C3 was evaluated by CRISPR/Cas9-based gene editing. Isotopic tracing analysis with deuterium 3 -labeled palmitate or carbon13-labeled glucose was conducted to investigate fatty acid (FA) and glucose carbon flux. Seahorse analysis was performed to assess the glycolytic flux and mitochondrial function. Selective AKR1C3 inhibitors were used to evaluate the effect of AKR1C3 inhibition on HCC tumor growth and induction of autophagy. Results: We found that long-term sorafenib treatment impairs fatty acid oxidation (FAO), leading to LD accumulation in HCC cells. Using multi-omics analysis in cultured HCC cells, we identified that aldo-keto reductase AKR1C3 is responsible for LD accumulation in HCC. Genetic loss of AKR1C3 fully depletes LD contents, navigating FA flux to phospholipids, sphingolipids, and mitochondria. Furthermore, we found that AKR1C3-dependent LD accumulation is required for mitigating sorafenib-induced mitochondrial lipotoxicity and dysfunction. Pharmacologic inhibition of AKR1C3 activity instantly induces autophagy-dependent LD catabolism, resulting in mitochondrial fission and apoptosis in sorafenib-resistant HCC clones. Notably, manipulation of AKR1C3 expression is sufficient to drive the metabolic switch between FAO and glycolysis. Conclusions: Our findings revealed that AKR1C3-dependent LD formation is critical for the adaptation to sorafenib in HCC through regulating lipid and energy homeostasis. AKR1C3-dependent LD accumulation protects HCC cells from sorafenib-induced mitochondrial lipotoxicity by regulating lipophagy. Targeting AKR1C3 might be a promising therapeutic strategy for HCC tumors.
Improving enterprise innovation performance is key for enterprises to obtain sustainable competitiveness. With the increasingly fierce market competition of technological and product innovation, acquiring external heterogeneous knowledge of alliance enterprises becomes core to improving innovation performance. In this paper, we constructed a theoretical model to present the effect of inter-enterprise knowledge heterogeneity and alliance network governance mechanisms on enterprise innovation performance. We selected high-tech enterprises as the research object for empirical research and reached the following conclusions: (1) Inter-enterprise knowledge heterogeneity has a positive effect on exploratory and exploitative innovation performance, and (2) trust and contract have a moderating effect on the relationship between inter-enterprise knowledge heterogeneity and enterprise innovation performance.
Under China’s distinct policy-driven agglomeration approach, the Chinese industrial park displays a low degree of industrial relevance and weak cooperation among enterprises in the park. The key to solving this problem lies in the guiding role of the park management committee. Accordingly, this study constructs a trilateral evolutionary game model of interenterprise cooperative innovation inside the industrial park under the supervision of the park management committee, leadership of the core enterprises, and with the participation of the small- and medium-sized enterprises. Through simulation analysis, this study explores the influencing factors behind the trilateral cooperative innovation strategy choices. Results show that (1) the park management committee, core enterprises, and small- and medium-sized enterprises have different degrees of influence on each other’s willingness to participate in cooperative innovation; (2) small- and medium-sized enterprises are sensitive to the management committee’s policy support, and core enterprises are sensitive to the management committee’s financial support; (3) core enterprises are more sensitive to penalties and income distribution than small- and medium-sized enterprises; (4) the degree of resource complementarity and trust among enterprises has a profound effect on core enterprises and small- and medium-sized enterprises’ willingness to participate in cooperative innovation.
In the face of increasing environmental pressures, environmentally friendly behaviour can help companies achieve truly sustainable growth. The issue of how to promote environmental behaviour among employees is a new challenge for leaders. However, studies do not systematically reveal the mechanisms of the effects of self-sacrificial leadership on employees’ organisational citizenship behaviour for the environment (OCBE). Based on social learning theory and the attitude–behaviour–context model, we investigated the impact of self-sacrificial leadership on employees’ OCBE by focusing on the mediating role of the corporate social responsibility (CSR) as perceived by employees, and the moderating role of the pro-environmental organisational climate (PEOC). The results of a field survey of 461 employees (small- and medium-sized enterprises) in China indicate that self-sacrificial leadership was positively related to employees’ OCBE; this relationship was partially mediated by employees’ perception of CSR. Moreover, PEOC strengthened the effect of employees’ perceived CSR on OCBE, and the mediating effect of employees’ perceived CSR on the relationship between self-sacrificial leadership and OCBE. Our findings not only help scholars understand the mechanism of the effect of self-sacrificial leadership on employees’ OCBE, but also provide insights for recommending integrated management models, social responsibility, and environmental protection.
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