Background In 2015, a Chinese expert consensus on photopatch testing (PPT) was established, based on European consensus methodology. Objectives To update current information on the prevalence of photoallergic contact dermatitis (PACD) to 20 photoallergens and their clinical relevance in the Chinese context. Methods A retrospective analysis of 2372 patients who performed PPT in a tertiary referral center in China between 2015 and 2019 was completed. A total of 1208 PACD reactions were observed in 897 (37.8%) patients, and 413 reactions were of current or past relevance. Results The proportion of reactions of current or past relevance was 34.2%. The most frequent photoallergens were chlorpromazine, thimerosal, potassium dichromate, and formaldehyde. The ultraviolet absorbers, benzophenone and Para‐aminobenzoic acid, showed opposite gender distribution to PACD. Twenty‐five patients (1.9%) developed PACD reactions to a newly added photoallergen preparation – fragrance mix I. Patients with chronic actinic dermatitis, widespread exposed‐site or generalized dermatitis, and older age were more likely to have PACD. Conclusions This study is the first to profile PACD reactions with clinical relevance in China. The prevalence of PACD to culprit photoallergens was affected by regional peculiarities. Attention needs to be paid to the age, body‐site distribution, and known diagnoses of patients for the identification of PACD.

Prurigo nodularis (PN) is a chronic skin disease characterized by intensely pruritic nodular lesions. 1,2 It has greater itch intensity and causes poorer quality of life than other common skin disorders. [2][3][4] Traditional therapies such as antihistamines, glucocorticoids and phototherapy are largely ineffective for PN. 2,3 The morbidity of PN is reportedly associated with race. Compared with Caucasians, PN disproportionately affects African Americans. 1,5 The pathogenesis of PN remains unclear. It is now considered a neuroimmune disorder caused by the itching-scratching cycle. 2,6 Defective skin barriers, dermal nerve fibre hyperplasia, increased neuropeptide secretion and the infiltration of immune cells and inflammatory mediators are typical histological features. 2,3 Two latest