Pseudophakic macular edema occurs commonly after phacoemulsification cataract surgery, even in the absence of complications and risk factors. This large retrospective study using structured EMR data quantified the RRs of PME and the risk with increasing ETDRS severity of DR. It highlights the need for prophylactic therapy, especially in those groups of eyes with the highest RRs.

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This randomized clinical trial compares the clinical effectiveness of intravitreal therapy with ranibizumab vs aflibercept vs bevacizumab for the management of macular edema secondary to central retinal vein occlusion.

LUMINOUS study confirms the effectiveness of ranibizumab for the treatment of neovascular age-related macular degeneration in real-world clinical practice. Visual acuity gains were higher among patients receiving a greater number of ranibizumab injections, particularly with three loading doses and lower BLVA levels. No new safety signals with ranibizumab were identified. Supplemental Digital Content is Available in the Text.

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This article reviews the safety, efficacy, and pharmacokinetics of several approved formulations of intravitreal corticosteroids for the treatment of diabetic macular edema (including triamcinolone acetonide, dexamethasone, and fluocinolone acetonide) and explores the relationship between kinetics, efficacy, and the development of adverse events.

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