Metal-organic frameworks are often used as a chemotherapeutic drug carrier due to their diverse metal sites and good acid degradation ability. Herein Co-doped Zn-MOF-5 nanoparticles with a high Co doping rate of 60% were synthesized for chemo-chemodynamic synergistic therapy of tumor. Co ions can mediate chemodynamic therapy through Fenton-like reaction and regulate the tumor microenviron-ment by consuming the reduced glutathione. The CoZn-MOF-5 shows high drug loading capacity with doxorubicin loading rate of 72.8%. The CoZn-MOF-5@PEG@DOX nanodrugs has a strong killing effect on 4T1 cancer cells, suggesting the chemo-chemodynamic synergistic effect on tumor therapy.
Fe-MIL100 with high Fe(II) content is synthesized at room temperature via a green synthesis process and used to form drug delivery system DOX@PEG-MIL100 by loading doxorubicin (DOX) and coating with polyethyleneglycol (PEG). This drug delivery system shows pH and glutathione (GSH) dualresponsive drug release behavior in response to tumor microenvironment and a high cytotoxicity in tumor cell line.
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