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The development of tumor-associated, stimuli-driven, turn-on near-infrared (NIR) fluorophores requires urgent attention because of their potential in selective and precise tumor diagnosis. Herein, we describe a NIR fluorescent probe (CyA-cRGD) comprised of a fluorescence reporting unit (a cyanine dye) linked with a GSH-responsive unit (nitroazo aryl ether group) and a tumor-targeting unit (cRGD). The NIR fluorescence of CyA-cRGD with sensitive and selective response to GSH can act as a direct off-on signal reporter for GSH monitoring. Notably, CyA-cRGD possesses improved biocompatibility compared with CyA, which is highly desirable for in vivo fluorescence tracking of cancer. Confocal fluorescence imaging confirmed the tumor-targeting capability and GSH detection ability of CyA-cRGD in tumor cells, normal cells, and coincubated tumor /normal cells and in the three-dimensional multicellular tumor spheroid. Furthermore, it was validated that CyA-cRGD could detect tumor precisely in GSH and integrin αβ high-expressed tumor-bearing mouse models. Importantly, it was confirmed that CyA-cRGD possessed high efficiency for early-stage tumor imaging in mouse models with tumor cells implanted within 72 h. This method provided significant advances toward more in-depth understanding and exploration of tumor imaging, which may potentially be applied for clinical early tumor diagnosis.

The radical suppression of the photodarkening effect and laser performance deterioration via H 2 loading were demonstrated in high-power Yb-doped fiber (YDF) amplifiers. The photodarkening loss at equilibrium was 114.4 dB/m at 702 nm in the pristine fiber, while it vanished in the H 2 -loaded fiber. To obtain a deeper understanding of the impact of photodarkening on laser properties, the evolution of the mode instability threshold and output power in fiber amplifiers was investigated. After pumping for 300 min, the mode instability threshold of the pristine fiber dropped from 770 to 612 W, and the periodic fluctuation of the output power became intense, finally reaching 100 W. To address the detrimental effects originating from photodarkening, H 2 loading was applied in contrast experiments. The output power remained stable, and no sign of mode instability was observed in the H 2 -loaded fiber. Moreover, the transmittance at 638 nm confirmed the absence of the photodarkening effect. The results pave the way for the further development of high-power fiber lasers.

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We systematically investigated the dependence of mode instability (MI) thresholds on bending diameters in ytterbium-doped fiber amplifiers. The MI thresholds of a fiber amplifier, which was based on a multimode ytterbium-doped fiber, were measured at various bending diameters. It is found that the correlation between MI thresholds and fiber bending diameters depends on the operation state of the active fiber. When the multimode active fiber is in the few-mode operation, the MI threshold is successfully raised from 717 W to 1084 W by increasing the fiber bending diameter from 11 cm to 60 cm. When the multimode active fiber operates in quasi-single mode, the MI threshold is raised from 717 W to 953 W by reducing the bending diameter from 11 cm to 8 cm. According to our experiments and previous reports, it is suggested that the influence of changing fiber bending diameter on MI might be closely related to the mode coupling effect.

A confined-doped fiber was fabricated by a modified chemical vapor deposition (MCVD) process based on refractive index matching technology. With theory and experiments, we compared the confined-doped fiber and normal-doped fiber. We found that the confined-doped fiber with a core of 35 μm and 0.07 numerical aperture could achieve single-mode output and improve the beam quality from 2.8 to 1.5 in the fiber laser. Meanwhile, it still possesses high laser efficiency and has good stability of beam quality with the increase in pump power. It suggests that the confined-doped fiber with a MCVD process may be the key material for a high-power fiber laser with excellent beam quality.

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