A series of stable (air, water stable and with good thermal stability) and hydrophobic ionic liquids based upon metal chelate anions were synthesized, which were shown to be effective, mild, and easy to recycle catalysts at the same time stable solvents for the oxidation of cyclohexene.
Background: Diabetic nephropathy (DN) affects about 40% of diabetes mellitus (DM) patients and is the leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) globally, especially in advanced countries. We aimed to explore the risk factors affecting the prognosis of DN, and to establish a prognostic evaluation line map. Methods:We analyzed 471 cases of DN from December 2011 to April 2020, and extracted the basic clinical factors, including gender, age, and history of diabetes. Analysis included that of associations between DN and hypertension, creatinine (CR), body mass index (BMI), and fundus lesions. Statistical analysis was performed using R software and the related R package. The above clinical factors were analyzed by both single-and multiple-factor Cox regression. The participants were divided into two groups, including a high risk and a low risk group. A Kaplan-Meier curve was drawn for survival analysis of the high and low risk groups, and the log-rank method was used for statistical testing. A receiver operating characteristic (ROC) curve was drawn with the area under the curve (AUC) calculated to evaluate the predictive effectiveness of the line map.Results: This study initially included 471 patients; however, 33 patients (7.0%) were lost to follow-up due to inaccessibility. A total of 93 cases (21.2%) died during the follow-up. The 3-year and 5-year renal survival rates were 74.5% and 22.6%, respectively. Single factor Cox analysis showed that the course of diabetes, fundus lesions, BMI, and grade of hypertension were risk factors for renal survival, and had adverse effects on prognosis (P<0.05). Multivariate Cox regression analysis showed that BMI and grade of hypertension were independent risk factors for survival of DKD, and had adverse effects on prognosis (P<0.05). Survival analysis showed that low risk group participants had significantly better survival rates than high risk group participants (P<0.05). The AUC was 0.742, which meant that the line map could accurately predict the survival rate of DN patients. Conclusions:The influence of risk factors on prognosis can be accurately evaluated by line diagram which can provide a basis for clinical decision making.
The Clique Partitioning Problem (CPP) is essential in graph theory with a number of important applications. Due to its NP-hardness, efficient algorithms for solving this problem are very crucial for practical purposes, and simulated annealing is proved to be effective in state-of-the-art CPP algorithms. However, to make simulated annealing more efficient to solve large-scale CPPs, in this paper, we propose a new iterated simulated annealing algorithm. Several methods are proposed in our algorithm to improve simulated annealing. First, a new configuration checking strategy based on timestamp is presented and incorporated into simulated annealing to avoid search cycles. Afterwards, to enhance the local search ability of simulated annealing and speed up convergence, we combine our simulated annealing with a descent search method to solve the CPP. This method further improves solutions found by simulated annealing, and thus compensates for the local search effect. To further accelerate the convergence speed, we introduce a shrinking factor to decline initial temperature and then propose an iterated local search algorithm based on simulated annealing. Additionally, a restart strategy is adopted when the search procedure converges. Extensive experiments on benchmark instances of the CPP were carried out, and the results suggest that the proposed simulated annealing algorithm outperforms all the existing heuristic algorithms, including five state-of-the-art algorithms. Thus the best-known solutions for 34 instances out of 94 are updated. We also conduct comparative analyses of the proposed strategies and show their effectiveness.
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