Conventionally, sulfones are prepared by oxidation of sulfides with strong oxidants. Now, a multicomponent reductive cross‐coupling involving an inorganic salt (sodium metabisulfite) for the straightforward construction of sulfones is disclosed. Both intramolecular and intermolecular reductive cross‐couplings were comprehensively explored, and diverse sulfones were accessible from the corresponding alkyl and aryl halides. Intramolecular cyclic sulfones were systematically obtained from five‐ to twelve‐membered rings. Naturally occurring aliphatic systems, such as steroids, saccharides, and amino acids, were highly compatible with the SO2‐insertion reductive cross‐coupling. Four clinically applied drug molecules, which include multiple heteroatoms and functional groups with active hydrogens, were successfully prepared via a late‐stage SO2 insertion. Mechanistic studies show that alkyl radicals and sulfonyl radicals were both involved as intermediates in this transformation.
Conventionally, sulfones are prepared by oxidation of sulfides with strong oxidants. Now, a multicomponent reductive cross‐coupling involving an inorganic salt (sodium metabisulfite) for the straightforward construction of sulfones is disclosed. Both intramolecular and intermolecular reductive cross‐couplings were comprehensively explored, and diverse sulfones were accessible from the corresponding alkyl and aryl halides. Intramolecular cyclic sulfones were systematically obtained from five‐ to twelve‐membered rings. Naturally occurring aliphatic systems, such as steroids, saccharides, and amino acids, were highly compatible with the SO2‐insertion reductive cross‐coupling. Four clinically applied drug molecules, which include multiple heteroatoms and functional groups with active hydrogens, were successfully prepared via a late‐stage SO2 insertion. Mechanistic studies show that alkyl radicals and sulfonyl radicals were both involved as intermediates in this transformation.
In this paper, we use chitosan as template molecule and N-[2-(dimethylamino) ethyl]-N’-[(2-hydroxy-4-vinylphenyl)] oxamide (H3eoxdmpe) as bridge ligand and directionally synthesize N-[2-(dimethylamino) ethyl]-N’-[(2-hydroxy-4-vinylphenyl)] oxamide dinuclear zinc-chitosan [Zn2 (eoxdmpe) (tetrachit)] (ClO4) coordination monomer. We study the interaction between complex and template molecules by ultraviolet spectrophotometry and the recognition ability of complex to monosaccharide molecule quantitatively by formula. The crystal structures of N-[2-(dimethylamino) ethyl]-N’-(2-hydroxy-4-vinylphenyl)] oxamide binuclear zinc-chitosan complex are determined and analyzed by X-ray single crystal diffractive technique and the results show that the metal coordination bond is a favorable binding activity for chitosan. This study provides an ideal model for the construction of metal coordination molecularly imprinted polymers which are selectively recognized by chitosan.
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