BackgroundSeveral studies have been conducted in recent years to evaluate the risk of type 2 diabetes mellitus (T2DM) and polymorphisms of interleukin (IL)-10. However, the results remain conflicting rather than conclusive. This meta-analysis aimed to summarize the current evidence from case-control studies that evaluated this association.MethodsWe carried out a search in Medline, EMBASE, and the Chinese National Knowledge Infrastructure (CNKI) database for relevant studies. Data were extracted using a standardized form and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of the association.Results10 studies were included in our meta-analysis and systemic review. Our meta-analysis indicated that IL-10 −1082A/G polymorphism was associated with the risk of T2DM (GA vs. AA: OR = 1.21, 95% CI = 1.03–1.14; GA/GG vs. AA: OR = 1.22, 95% CI = 1.05–1.41), whereas there was no association between IL-10 −592C/A (CC/CA vs. AA: OR = 1.07, 95% CI = 0.59–1.93) or -819C/T (CC/CT vs. TT: OR = 0.93, 95% CI = 0.49–1.75) polymorphism and T2DM risk was found in our study.ConclusionsThis meta-analysis provides strong evidence that IL-10 −1082A/G polymorphism associated with risk of T2DM. However, no association of the IL-10 −592C/A or −819C/T polymorphism with T2DM risk was found. Additional well-designed large studies were required for the validation of our results.
BackgroundTo evaluate the level and correlation of serum neuropeptide cakiNnin gene-elated peptide (CORP), somatostatin (SS) and inflammatory factors (CRP, TNF-o, MCP-1 and sICAM-1) in patients with coronary atherosclerotic heart disease (CAD) complicated with type 2 diabetes mellitus (DM), to explore the mechanism of diabetic patients prone to complicated CAD.MethodsPatients were divided into three groups according to corcmary angiography results and whether there was a history of type 2 diabetes: control group (no CAD or DM; n 58), CAD group (stable CAD without DM; n 68) and DM+CAD group (stable CAD+DM; n =66). The age, sex ratio and body mass index (BMI) of the three groups were balanced, and the indexes of serum CORP, SS and inflammatory factors (CRP, TNE-a, IL-113, MCP-1 and sICAM-1) were measured by ELASA method. The relationship between serum CORP, SS and inflammatory factors (CRP, TNE-¢,11,-1), MCP-1 and sICAM-1) were analyzed by Spearman correlation analysis, and the risk factors f CAD were analysed by binary logistic regression model.ResultsThere were significant differences between neuropeptides (CORP, SS) and inflammatory factors (CRP, TNT', IL-I, MCP-1 and sICAM-1) in the th©© groups. Compared with the control group and the CAD group, CGRP and SS were decreased (P < 0.05), and inflammatory factors were significantly increased (P < 0.05) in the DMTCAD group. CGRP and SS were negatively correlated with inflammatory factors. Logistic regression model showed that CORP, SS, 11-10 and MCP-1 were independent risk factors for CAD (P <0.05). ConclusionCompared with the control group and the CAD group, patients in the DMTCAD group had less CGRP and SS but more inflammatory factors. Moreover, the inflammabry factors were negatively correlated with neuropeptides, and neuropeptides and some inflammatory factors are independent risk factors for CAD. This suggests that the TRPV1 injury in the sensory nerve endings and the reduction of neuropeptides release in type 2 diabetic patients may increase the risk of CAD. The mechanism may include that these neuropeptides may inhibit the inflammatory response to some extend
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