Given the emerging role of microRNA in tumor disease progression, we investigated the association between miRNA 10b expression, liver metastasis, and clinicopathological of colorectal cancer (CRC). Two hundred and forty‐six pairs of samples (including CRC samples and normal adjacent tissues) from CRC patients were collected from May 2004 to May 2009. All samples verified to contain at least 80% tumor cells, and were immediately frozen in liquid nitrogen and stored at −80°C or fixed in 10% formalin for paraffin embedding. The expression of miRNA‐10b in CRC tissues was evaluated using a quantitative real‐time polymerase chain reaction RT‐PCR. Correlation between miR‐10b expression and poor clinicopathological of CRC patients were analyzed using Student's t‐tests and Chi‐square tests. A Kaplan–Meier survival curve was generated following a log‐rank test. miR‐10b expression was up‐regulated in CRC tissues (P < 0.0001) and in patients diagnosed as colorectal liver metastasis (CLM) at initial involvement or during follow‐up. When the Tumor Node Metastasis (TNM) stage was taken into consideration, the expression levels of miR‐10b were positively correlated with advanced TNM stages. In addition, the miR‐10b expression of patients diagnosed as CLM at initial involvement was significantly higher than those without liver metastasis (nCLM). Similarly, those patients developed with CLM during follow‐up (FCLM) was also markedly higher than those with nCLM. miR‐10b expression was also found correlated with advanced stage (P < 0.0001), lymph node metastasis (P = 0.025), venous infiltration (P = 0.007), poorer differentiation (P = 0.002), and served as an independent prognostic factor of poor overall survival (P < 0.0001). This study demonstrated the expression of miR‐10b had strong potential to serve as a noninvasive biomarker for CRC prognosis and predicting liver metastasis.
Wenquan pluton is situated in the western Qinling mountains and is adjacent to the south of the Shangdan suture zone. Through analyses of regional tectonics and the anisotropy of low‐field magnetic susceptibility (AMS) together with rock magnetism of 125 oriented samples, the emplacement mechanism of the pluton is studied. The values of most mean susceptibilities (km) show a wide variation range. Thermomagnetic curves demonstrate that the paramagnetic minerals such as biotite, acting as the main magnetic carriers, made dominant contributions to the magnetic susceptibility of the samples with low values, also including a small contribution to remanence from small amount of magnetite. The magnetite, however, acted as the dominant magnetic carrier of the samples with high magnetic susceptibility values. The corrected anisotropy degree (PJ ) less than 1.2 can be regarded as flow magnetic fabrics based on microscopic observations. The shape parameters (T) of most of magnetic susceptibility ellipsoid display that the Wenquan pluton is dominated by oblate compressional fabric, and the magnetic foliations are dominant over magnetic lineations. In addition, it is well marked that most magnetic foliations of the samples on the border seem parallel to the edge of the granite pluton, which have relatively steep inclinations, and interior ones appear relatively disordered besides magnetic lineations. Hence it can be revealed that the magnetic fabrics of the pluton are mainly formed by the lateral compression during the emplacement. Though the magnetic fabrics show N‐NEE and SW directed compression as a whole, the compression caused by the closure of the Shangdan suture zone during the Indo‐China period became much weaker than that in the main orogenic stage. Consequently it can be concluded that the weak compression setting can be reflected by the characteristics of magnetic fabrics when the pluton emplaced, and furthermore the relatively sustained and even extensional environment was probable and understandable, which was consistent with the regional tectonic setting in the extension stage of the emergence of delamination when the Qinling orogenic belt evolved to post‐collision stage.
As an important component of large engines, inter-shaft bearing is easily damaged due to its poor working conditions. By analyzing the time–frequency distribution rules of fault signals and the evolution law of micro-faults, the bearing failure mechanism can be revealed, and the bearing failure can be monitored in real time and prevented in advance. For the purpose of studying the mechanism of inter-shaft bearing faults, a 4-DOF (degree of freedom) dynamic model of inter-shaft bearing with local defects considering elasto-hydrodynamic lubrication (EHL) is proposed. Based on the established dynamic model, the impact characteristics and distribution rules of the fault signals of the bearing are accurately simulated, and the evolution law of the micro-faults is also analyzed. The effects of different speeds, loads and defect widths on maximum value (MV), absolute mean value (AMV), effective value (EV), amplitude of square root (AST), kurtosis factor (KF), impulse factor (IF), peak factor (PF) and shape factor (SF) are obtained. The findings show that the vibration amplitude of the bearing increases with the increase in defect size, and the faults are easier to diagnose accordingly. At the same time, PF, KF and IF are very sensitive to the initial failure of bearings. With the development of faults, the overall trend of AMV, AST and EV are relatively stable. The PF is sensitive to the change of rotating speeds and defect widths. The SF is insensitive to the change of rotating speeds, loads and defect widths. This lays a foundation for the research of monitoring and diagnosis methods of aeroengine inter-shaft bearing fault.
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