Blast, caused by the fungal pathogen Pyricularia grisea, is the most devastating disease of rice worldwide. Knowledge of the pathotype composition of the pathogen in rice fields is essential for rational deployment of resistance genes in rice breeding programs. In this study, we assayed the pathotypes of the pathogen populations using samples recently collected from 13 major rice-growing provinces of central and southern China. In all, 792 single spore isolates were tested for pathogenicity reactions using 13 host differentials consisting of six indica and seven japonica near-isogenic lines (NILs). The compositions of the pathogen populations were complex; 48 pathotypes were identified with the indica NILs, 82 pathotypes were detected with the japonica NILs, and a total of 344 pathotypes were identified with both indica and japonica NILs. There were large differences in distribution of the pathotypes among the different rice-growing areas. Even neighbor provinces seemed to differ sharply in types and frequencies of the most prevalent pathotypes. There was also a large difference in the frequencies of the isolates producing compatible reactions on the NILs, indicating the difference in frequencies of avirulence genes in the pathogen populations. The data provided very useful information for formulating strategies for improving blast resistance in rice breeding programs.
Aim: It has been reported that oxidized low-density lipoprotein (oxLDL) forms a stable and non-dissociable complex with β2-glycoprotein I (β2GPI) and that IgG anti-β2GPI autoantibodies are able to recognize this complex, thus facilitating macrophage-derived foam cell formation in patients with antiphospholipid syndrome (APS). However, the immunopathological mechanisms of oxLDL/β2GPI complexes in promoting foam cell formation are not fully understood. In this study, we examined the role of toll-like receptor 4 (TLR4) in the oxLDL/β2GPI/anti-β2GPI complex-induced transformation of mouse peritoneal macrophages to foam cells.
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