A novel gene coding for the pre-B-cell colony-enhancing factor (PBEF)

The study indicated that 98-kDa mite paramyosin is an important allergen.

Mite paramyosin is very similar to other known paramyosins. The human IgE and IgG epitopes are scattered throughout the entire molecule. Data also indicate the presence of unique IgE and IgG epitopes in Der f 11.

No abstract

T-cell immunoglobulin- and mucin-domain-containing molecule 3 (TIM-3) is a novel transmembrane protein that is involved in the regulation of T-helper 1 (Th1)-cell-mediated immunity. This study was undertaken to investigate the association of TIM-3 polymorphisms with susceptibility to renal cell carcinoma (RCC) in the Chinese population. Blood was collected from 322 RCC patients and 402 healthy controls. Three polymorphisms in the TIM-3 gene (-1516G/T, -574G/T, and +4259T/G) were genotyped by polymerase chain reaction-restriction fragment length polymorphism. Results showed that the -574G/T and +4259T/G polymorphisms were significantly increased in the RCC cases (odds ratio [OR] = 2.77, 95% confidence interval [CI], 1.42-5.39, p = 0.002 and OR = 3.22, 95% CI, 1.64-6.35, p<0.001). When analyzing the haplotypes of TIM-3 polymorphisms, TTG (-1516, -574, and +4259) revealed a significant correlation with RCC (OR = 3.55, 95% CI, 1.13-11.2, p = 0.033). In addition, the prevalence of +4259T/G polymorphism was higher in RCC cases with metastasis than in those without metastasis (7.4% vs. 3.5%, p = 0.041). These results suggest that polymorphisms in the TIM-3 gene are new risk factors for RCC and that TIM-3 may play important roles in regulating the prognosis of this disease.