This article is the first investigation on the dual permeability flow issue for horizontal well-production in a naturally fractured dual-porosity reservoir. Based on the inter-porosity flow from matrix system to fracture system and treating the media directly connected with horizontal wellbore as matrix and fracture systems, we established a model of horizontal well-production and then solved the model using some modern mathematical methods, such as Laplace integral transformation, separation of variables, eigenvalue, and eigenfunction. Later in the article, we obtained the standard log-log type curves using numerical simulation and analyzed the transient flow behavior thoroughly, which showed it is dual porosity and dual permeability flow behavior. The numerical simulation results showed that there are obvious differences between dual permeability and single permeability models. The dual permeability flow behavior accelerates energy supplement during production and reduces the classical matrix-fracture (V-shaped) response. We also showed that type curves characteristics are affected by external boundary conditions, the parameter κ, ω f and λ mf , etc. The research results show that our model would be a good semi-analytical model supplied to users. Because the single permeability modeling ignores the direct fluid supply from matrix to wellbore, we recommend using the dual permeability modeling to make well testing and rate decline interpretation in real case studies.

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Urinary mutagenicity reflects systemic exposure to complex mixtures of genotoxic/ carcinogenic agents and is linked to tumor development. Coal combustion emissions (CCE) and diesel engine exhaust (DEE) are associated with cancers of the lung and other sites, but their influence on urinary mutagenicity is unclear. We investigated associations between exposure to CCE or DEE and urinary mutagenicity. In two separate cross-sectional studies of nonsmokers, organic extracts of urine were evaluated for mutagenicity levels using strain YG1041 in the Salmonella (Ames) mutagenicity assay. First, we compared levels among 10 female bituminous (smoky) coal users from Laibin, Xuanwei, China, and 10 female anthracite (smokeless) coal users. We estimated exposure-response relationships using indoor air concentrations of two

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