Purpose Long noncoding RNAs have been studied more and more as potential prognostic markers. However, the prognostic of LINC00460 in clear cell renal cell carcinoma (ccRCC) has not been explored. In this study, the potential role of LINC00460 was investigated in ccRCC. Patients and Methods One hundred thirteen pairs of ccRCC tissues and para-normal tissues were collected. The expressions of LINC00460 in these tissues and ccRCC cells were evaluated via qRT-PCR. The prognostic value of LINC00460 was accessed with the use of Kaplan–Meier analysis and Cox proportional hazards model analysis. The influence of LINC00460 on ccRCC cell proliferation, migration, and invasion was determined via cell counting kit-8 (CCK-8) and Transwell assays. Results The results revealed that LINC00460 was significantly enhanced in ccRCC tissues, as well as in ccRCC cell lines. The overexpression of LINC00460 was significantly associated with lymph node metastasis and TNM stage, and lead to poor overall survival. Knockdown of LINC00460 reduces the cell ability of proliferation, migration, and invasion. LINC00460 could sponge to miR-149-5p. Conclusion LINC00460 may be developed as a prognostic biomarker and molecular therapy target for ccRCC.
Neoadjuvant chemotherapy is the standard treatment for patients with advanced localized breast cancer, but today it has found a good place in the early stages to achieve a negative surgical margin and increase the possibility of breast preservation. Numerous studies have shown that patient survival increases with a complete pathological response in the relationship of some immunological molecules known as immunohistochemistry markers. The aim of this study was to investigate the complete pathological response in the relationship between PRMT5 and FOXP1 expression. In a cross-sectional study of breast cancer patients in stages I to III, who were treated with Neoadjuvant chemotherapy at the Breast Cancer Research Institute during the years 2018 to 2019, were examined. A complete pathological response was obtained in cases where no tumors remained in the breast and axillary tissue after surgery. Immunohistochemical analyzes for FOXP1, PRMT5, and PR and ER biomarkers of the tumor were conducted. Data were analyzed using descriptive and analytical statistics by SPSS v. 21 software. 157 patients with a mean age of 47.5 ±16.2 years were included in the study. Our results revealed that there was no significant difference between the foxp1 Positive and Negative patients, in terms of cancer stage, metastasis, being PR or ER-positive (P>0.05). While being PRMT5+/- had a significant relationship with FOXP1 expression (p=0.001). In the case of the response to treatment, there was a significant association between a complete response and being foxp1 + (p=0.01). While in other immunohistochemistry markers, no significant association was found (P>0.05). Our study revealed no association of foxp1 and PRMT5 with other biomarkers of breast cancer and clinical progress of the disease. Our study revealed no association of foxp1 and PRMT5 with other biomarkers of breast cancer and clinical progress of the disease.
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