After restrictive guidelines regarding GBCA administration were instituted, no new cases of NSF were identified among 52,954 contrast-enhanced MR examinations, including those performed in patients with an eGFR lower than 60 mL/min/m(2).

In recent years, the shrinkage of Poyang Lake, the largest freshwater lake in China, has raised concerns for society. The regulation of the Three Gorges Dam (TGD) has been argued to be a cause of the depletion of the lake by previous studies. However, over the past few decades, the lake’s surface water dynamic has remained poorly characterized, especially before the regulation of the TGD (2003). By calculating the inundation frequency with an index- and pixel-based water detection algorithm on Google Earth Engine (GEE), this study explored the spatial–temporal variation of the lake during 1988–2016 and compared the differences in Poyang Lake’s water body between the pre- and post-TGD periods. The year-long water body area of the lake has shown a significant decreasing trend over the past 29 years and has shifted to a smaller regime since 2006. The inundation frequency of the lake has also generally decreased since 2003, particularly at the central part of the lake, and the effects of this trend have been most severe in the spring and autumn seasons. The lake’s area has shown significant correlation with the precipitation of the Poyang Lake Basin on an inner-annual scale. The drivers of and relevant factors relating to the inter-annual variation of the lake’s surface water should be further investigated in the future.

Purpose Evaluate 18F-fluoroestradiol (FES) PET/CT as a biomarker of estrogen receptor (ER) occupancy and/or downregulation during phase I dose escalation of the novel ER targeting therapeutic GDC-0810, and help select drug dosage for subsequent clinical trials. Experimental Design In a phase I clinical trial of GDC-0810, patients with ER-positive metastatic breast cancer underwent FES PET/CT before beginning therapy and at cycle 2, day 3 of GDC-0810 therapy. Up to five target lesions were selected per patient, and FES SUV corrected for background was recorded for each lesion pre-therapy and on-therapy. Complete ER downregulation was defined as ≥ 90% decrease in FES SUV. The effect of prior tamoxifen and fulvestrant therapy on FES SUV was assessed. Results Of 30 patients who underwent paired FES-PET scans, 24 (80%) achieved ≥ 90% decrease in FES avidity, including 1 of 3 patients receiving 200 mg/day, 2 of 4 patients receiving 400 mg/day, 14 of 16 patients receiving 600 mg/day, and 7 of 7 patients receiving 800 mg/day. Withdrawal of tamoxifen two months prior to FES PET/CT and withdrawal of fulvestrant six months prior to FES PET/CT both appeared sufficient to prevent effects on FES SUV. A dosage of 600 mg GDC-0810 per day was selected for phase II in part due to decreases in FES SUV achieved in phase I. Conclusion FES PET/CT was a useful biomarker of ER occupancy and/or downregulation in a phase I dose escalation trial of GDC-0810 and helped select the dosage of the ER antagonist/degrader for phase II trials.

MET-PET scanning shows a significant decrease in metabolic signal at 1 month after chemoradiation compared with the immediate postoperative period, even when T2/fluid-attenuated inversion recovery changed little. MGMT promoter methylation status further predicts differential metabolic responses. MET-PET may be a useful tool for delineation of radiation targets and assessment of response.

SPECT/CT has high sensitivity, specificity, and negative predictive value, but may overestimate relevant nodal basins in sentinel lymph node biopsy.

Mobile digital specimen radiography allows high diagnostic confidence for verification of target excision in breast specimens across target types, despite lower image quality. Substituting this modality for conventional digital mammography can eliminate delays associated with specimen transport, potentially decreasing surgical duration and increasing operating room throughput.

Objective. Talc pleurodesis is a common procedure performed to treat complications related to lung cancer. The purpose of our study was to characterize any thoracic nodal findings on FDG PET/CT associated with prior talc pleurodesis. Materials and Methods. The electronic medical record identified 44 patients who underwent PET/CT between January 2006 and December 2010 and had a history of talc pleurodesis. For each exam, we evaluated the distribution pattern, size, and attenuation of intrathoracic lymph nodes and the associated standardized uptake value. Results. High-attenuation intrathoracic lymph nodes were noted in 11 patients (25%), and all had corresponding increased FDG uptake (range 2–9 mm). Involved nodal groups were anterior peridiaphragmatic (100%), paracardiac (45%), internal mammary (25%), and peri-IVC (18%) nodal stations. Seven of the 11 patients (63%) had involvement of multiple lymph nodal groups. Mean longitudinal PET/CT and standalone CT followups of 15 ± 11 months showed persistence of both high-attenuation and increased uptake at these sites, without increase in nodal size suggesting metastatic disease involvement. Conclusions. FDG avid, high-attenuation lymph nodes along the lymphatic drainage pathway for parietal pleura are a relatively common finding following talc pleurodesis and should not be mistaken for nodal metastases during the evaluation of patients with history of lung cancer.

Eighty-three of 1103 (7.5%) diuretic renograms were performed on patients with sulfonamide allergies. Two instances of minor rash occurred. No serious reactions occurred. Furosemide is associated with an extremely low risk of minor reactions in patients with sulfonamide allergies.