Sulfur-doped polyimide (SPI) photocatalysts were synthesized for the first time via an in situ thermal copolymerization method using sublimed sulfur (S4) as a dopant. Sulfur doping not only extended the absorption range of polyimide (PI) for visible light but also enhanced the oxidation ability of the photoinduced hole. The doped sulfur substitutes for the lattice nitrogen in triazine rings of PI to form the S-C bond and changes the distribution of negative charge in the two-dimensional plane of PI. The enhanced photocatalytic activity of SPI in the degradation of methyl orange is ascribed to the strong oxidation ability of the photoinduced hole of SPI and an effective suppression to the recombination of electrons and holes.
N-α-acetyltransferase D (NatD) mediates N-α-terminal acetylation
(Nt-acetylation) of histone H4 known to be involved in cell growth. Here we report
that NatD promotes the migratory and invasive capabilities of lung cancer cells in
vitro and in vivo. Depletion of NatD suppresses the epithelial-to-mesenchymal
transition (EMT) of lung cancer cells by directly repressing the expression of
transcription factor Slug, a key regulator of EMT. We found that Nt-acetylation of
histone H4 antagonizes histone H4 serine 1 phosphorylation (H4S1ph), and that
downregulation of Nt-acetylation of histone H4 facilitates CK2α binding to histone
H4 in lung cancer cells, resulting in increased H4S1ph and epigenetic reprogramming
to suppress Slug transcription to inhibit EMT. Importantly, NatD is commonly
upregulated in primary human lung cancer tissues where its expression level
correlates with Slug expression, enhanced invasiveness, and poor clinical outcomes.
These findings indicate that NatD is a crucial epigenetic modulator of cell invasion
during lung cancer progression.
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