The present study investigated the association between the presence of periodontitis and aortic calcification (AC) risk among Chinese adults. A total of 6059 individuals who underwent regular health check-ups and received a diagnosis of periodontitis between 2009 and 2016 were included. The outcome was AC, assessed by a chest low-dose spiral CT scan. Cox proportional hazards regression analysis was used to assess the association between periodontitis and AC risk after adjusting for several confounders. After a median follow-up period of 2.3 years (interquartile range: 1.03–4.97 years), 843 cases of AC were identified, with 532 (12.13%) and 311 (18.59%) patients in the non-periodontitis group and periodontitis group, respectively. Multivariate analyses demonstrated that, compared with those without periodontitis, the hazard ratio and 95% confidence interval for AC risk in participants with periodontitis was 1.18 (1.02–1.36) ( P = .025) in the fully adjusted model. Stratified analyses showed that the positive relationship between periodontitis and AC was more evident in males and participants <65 years of age (pinteraction = .005 and .004, respectively). Our results show that the presence of periodontitis was positively associated with AC among Chinese adults, especially among males and younger participants.
Aims/Introduction: The current literature suggests that men with diabetes have a lower prostate-specific antigen concentration than men without diabetes, but the causal association remains unclear. We aimed to investigate the association between serum prostate-specific antigen concentrations and the risk of type 2 diabetes mellitus in a cohort study of a Chinese population. Materials and Methods: We designed a cohort study that comprised 16,811 initially non-diabetic Chinese men who received annual health checkups between 2009 and 2016. The outcome of this study was type 2 diabetes mellitus, identified by medical diagnosis, self-reportage, medication use, fasting glucose, 2-h post oral glucose or glycated hemoglobin measurements. Cox proportional hazards models were carried out to evaluate the association. Results: During a median follow-up period of 3.8 years (interquartile range 1.91-5.73 years), 1,260 participants developed incident type 2 diabetes mellitus. The multivariable model, adjusted for various potential confounders, showed that serum prostate-specific antigen concentrations were inversely related to type 2 diabetes mellitus risk (P for trend = 0.014). Compared with the lowest quartile of serum prostate-specific antigen, the hazard ratio and 95% confidence intervals of type 2 diabetes mellitus risk for quartile 2-4 were 0.84 (0.66-1.07), 0.75 (0.59-0.94) and 0.77 (0.62-0.96), respectively. Subgroup analyses suggested the inverse relationship was more prominent in overweight or obese participants (P for interaction = 0.013). Conclusions: High serum prostate-specific antigen concentration was associated with a low risk of type 2 diabetes mellitus in Chinese men. Future studies are required to confirm these findings and investigate underlying mechanisms. increase to 642 million by 2040 1 . The prevalence of type 2 diabetes mellitus has rapidly increased in Asian populations, and China has become a major center of the diabetes epidemic 2 . A national cross-sectional study carried out in 2017 suggested that 12.8% of adults living in China had diabetes, as diagnosed using criteria outlined by the American Diabetes Association, and estimated that the total number of individuals with diabetes in mainland China was 129.8 million 3 . Given the growing
Purpose: The main objective of the study was to translate, validate, and compare the Chinese ORTO scales (ORTO-15 and ORTO-R). The secondary objective was to assess factors that may be related with risk of orthorexia nervosa (ON). Methods: Two cross-sectional surveys were conducted on March-to-June 2021 for ORTO-15) and April 2022 (ORTO-R). ORTO questionnaires were translated into Chinese using the forward-backward-forward method. Exploratory factor analysis, discriminant validity and con rmatory factor analysis (CFA) were used to examine the construct validity of the assessment questionnaires. The internal consistency was assessed by using the Cronbach alpha coe cient and the test-retest reliability. Multivariate linear regression analysis was used to explore potential impact factors related with ON scores.Results: Totally, 1289 and1084 eligible participants were included for the study of ORTO-15 and ORTO-R, with the mean age of 20.9±2.0 years and 21.0±2.3 years. The internal consistency of Chinese ORTO-15 scale and ORTO-R scale were both satisfactory (α=0.79, ICC=0.79; α=0.77, ICC=0.82). A two-factor solution of ORTO-R was characterized by acceptable goodness-of-t, whereas the three-factor solution of ORTO-15 showed relatively poor t. Multivariate linear regression indicated that physical activities and mental disorders were positively associated with ON risk assessed by both ORTO-R and ORTO-15. Conclusion:The Chinese ORTO-R scale were a more reliable tool to screen for ON tendencies than the Chinese version of ORTO-15. Mental disorders and physical activities might be associated with the increased ON risk.Level of evidence Level V (descriptive cross-sectional study).
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