An atom Michelson interferometer is implemented on an "atom chip." The chip uses lithographically patterned conductors and external magnetic fields to produce and guide a Bose-Einstein condensate. Splitting, reflecting, and recombining of condensate atoms are achieved by a standing-wave light field having a wave vector aligned along the atom waveguide. A differential phase shift between the two arms of the interferometer is introduced by either a magnetic-field gradient or with an initial condensate velocity. Interference contrast is still observable at 20% with an atom propagation time of 10 ms.

Abstract:In a recent experiment [1], it was observed that a sequence of two standing wave square pulses can split a BEC at rest into +/-2 k diffraction orders with almost 100% efficiency.By truncating the Raman-Nath equations to a 2-state model, we provide an intuitive picture that explains this double square pulse beamsplitter scheme. We further show it is possible to optimize a standingwave multi square pulse sequence to efficiently diffract an atom at rest to symmetric superposition of +/-2n k diffraction order with n>1. The approach is considered to be qualitatively different from the traditional light pulse schemes in the Bragg or the Raman-Nath region, and can be extended to more complex atomic optical elements that produce various tailored output momentum states from a cold atom source.2

We demonstrate a direct resonant interaction between the mechanical motion of a mesoscopic resonator and the spin degrees of freedom of a sample of neutral atoms in the gas phase. This coupling, mediated by a magnetic particle attached to the tip of the miniature mechanical resonator, excites a coherent precession of the atomic spins about a static magnetic field. The novel coupled atom-resonator system may enable development of low-power, high-performance sensors, and enhance research efforts connected with the manipulation of cold atoms, quantum control, and high-resolution microscopy.

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A magnetic waveguide structure allows switching of neutral atoms between two guides. The switch consists of lithographically patterned current-carrying wires on a sapphire substrate. By selectively sending current through a particular set of wires, we select the desired output port of an incoming beam. We utilize two different magnetic-guiding schemes to adiabatically manipulate the atom trajectory.

BackgroundMultiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) mediated by autoimmunity. No objective clinical indicators are available for the diagnosis and prognosis of MS. Extracellular proteins are most glycosylated and likely to enter into the body fluid to serve as potential biomarkers. Our work will contribute to the in-depth study of the functions of extracellular proteins and the discovery of disease biomarkers.MethodsMS expression profiling data of the human brain was downloaded from the Gene Expression Omnibus (GEO). Extracellular protein-differentially expressed genes (EP-DEGs) were screened by protein annotation databases. GO and KEGG were used to analyze the function and pathway of EP-DEGs. STRING, Cytoscape, MCODE and Cytohubba were used to construct a protein-protein interaction (PPI) network and screen key EP-DEGs. Key EP-DEGs levels were detected in the CSF of MS patients. ROC curve and survival analysis were used to evaluate the diagnostic and prognostic ability of key EP-DEGs.ResultsWe screened 133 EP-DEGs from DEGs. EP-DEGs were enriched in the collagen-containing extracellular matrix, signaling receptor activator activity, immune-related pathways, and PI3K-Akt signaling pathway. The PPI network of EP-DEGs had 85 nodes and 185 edges. We identified 4 key extracellular proteins IL17A, IL2, CD44, IGF1, and 16 extracellular proteins that interacted with IL17A. We clinically verified that IL17A levels decreased, but Del-1 and resolvinD1 levels increased. The diagnostic accuracy of Del-1 (AUC: 0.947) was superior to that of IgG (AUC: 0.740) with a sensitivity of 82.4% and a specificity of 100%. High Del-1 levels were significantly associated with better relapse-free and progression-free survival.ConclusionIL17A, IL2, CD44, and IGF1 may be key extracellular proteins in the pathogenesis of MS. IL17A, Del-1, and resolvinD1 may co-regulate the development of MS and Del-1 is a potential biomarker of MS. We used bioinformatics methods to explore the biomarkers of MS and validated the results in clinical samples. The study provides a theoretical and experimental basis for revealing the pathogenesis of MS and improving the diagnosis and prognosis of MS.

We demonstrate efficient loading of neutral atoms into a magnetic waveguide produced by the magnetic fields of microfabricated current-carrying conductors. The lithographically patterned conductors on this "atom chip" can be used to make a variety of guiding and trapping structures for manipulating cold atoms and Bose-Einstein condensates. A three-chamber vacuum apparatus collects atoms in a magneto-optical trap, precools them via evaporative cooling, and delivers them to the final chamber containing the atom chip. We describe in detail how the precooled atomic cloud is transferred from a macroscopic magnetic Ioffe-Pritchard trap to the microscopic magnetic waveguide on the atom chip 21 cm away. Permanent magnets provide a confining two-dimensional quadrupole field to guide the atoms between the two chambers while longitudinally the cloud is allowed to freely expand during the transfer. Strategically placed coils are used to control the longitudinal size and speed of the atomic cloud as it is loaded on the atom chip.