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Purpose The aim of this study was to determine whether hydroxypropylcellulose (HPC) coating of polyethylene terephthalate (PET) artificial ligaments enhances graft osseointegration in the bone tunnel. Methods Thirty New Zealand white rabbits underwent artificial ligament graft transplantation in the bilateral proximal tibia tunnels. One limb was implanted with an HPC-coated PET graft, and the contralateral limb was implanted with a non-HPC-coated PET graft as a control. The rabbits were then randomly sacrificed at weeks four and eight after surgery for biomechanical testing, histological examination, and histomorphometric and real-time polymerase chain reaction analysis.

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Polystyrene (PS)/poly(ethylene glycol dimethacrylate) composite polymer particles containing hinokitiol (HT) were produced by suspension polymerization for ethylene glycol dimethacrylate droplets by the dissolution of HT and PS in poly(vinyl alcohol) aqueous solution. The composite particle had a hollow structure in which HT was included. The evaporation rate of HT from the composite particles became slower than that of pure HT.