The osteoporotic hip and vertebral fractures caused excess mortality rates in this population of Mainland China. The current diagnosis and medical treatment following the fragility fractures is still insufficient in Mainland China.

Treatment procedures for anterior disc displacement (ADD) of temporomandibular joint (TMJ) are far from reaching a consensus. The aim of the study was to evaluate disc status changes of anterior disc displacement with reduction (ADDWR) and without reduction (ADDWoR) comparatively, to get a better understanding of the disease progress without intervention. This longitudinal retrospective study included 217 joints in 165 patients, which were divided into ADDWR group and ADDWoR group based on magnetic resonance imaging (MRI) examination. The joints were assessed quantitatively for disc length and displacement distance at initial and follow-up visits. Disc morphology, which was classified in 5 types, was also evaluated. Paired t-test and Wilcoxon signed rank test were used to assess intra-group differences and independent t-test for inter-group differences. Moreover, analysis of covariance was applied to analyze influential factors for changes in disc length and displacement distance. According to our results, discs tended to become shorter, move further forward and distort more seriously in ADDWoR group than in ADDWR group after follow-up. Moreover, discs were prone to become shorter and more anteriorly displaced in teenagers, type I and III morphologies, advanced Wilkes stages, or those with joint effusion. Follow-up period seemed to be not critical.

BackgroundThe combination of immune checkpoint blockade and chemotherapy has revolutionized the treatment of advanced gastric cancer (GC). It is crucial to unravel chemotherapy-induced tumor microenvironment (TME) modulation and identify which immunotherapy would improve antitumor effect.MethodsIn this study, tumor-associated immune cells (TAICs) infiltration in residual tumor after neoadjuvant chemotherapy (NAC) together with 1075 cases of treatment-naïve GC patients was analyzed first. Then we performed multiplex fluorescence staining of a panel of immune markers (CD3, CD4, CD8, FOXP3 and PDL1) and T cell receptor β-chain sequencing to phenotype and enumerate T cell subpopulations and clonal expansion in paired GC samples (prechemotherapy and postchemotherapy) from another cohort of 30 cases of stage II/III GC patients.ResultsInfiltration of CD68+ macrophages in residual tumors after NAC was significantly decreased compared with treatment-naïve GC patients, while no significant difference observed with respect to other immune markers. In residual tumors, post-NAC CD8 +T cells and CD68+ macrophages levels were significantly associated with chemotherapy response. Post-NAC CD8+ T cell levels remained as an independent predictor for favorable prognosis. Furthermore, when comparing the paired samples before and after NAC from 30 cases of stage II/III GC patients, we found FOXP3+ regulatory T cells proportion significantly decreased after chemotherapy. Pre-NAC FOXP3+ T reg cells level was much richer in the response group and decreased more significantly in the stromal compartment. CD8+ cytotoxic T lymphocytes levels were elevated after chemotherapy, which was more significant in the group treated with XELOX regimen and in patients with better response, consistent with the TCR diversity elevation.ConclusionsThese findings have deepened our understanding of the immune modulating effect of chemotherapy and suggest that the immune profile of specimens after standard chemotherapy should be considered for the personalized immunotherapy to ultimately improve clinical outcome in patients with GC.

Since the 1980s, the composition of the fresh apple market has shifted from three fourths Red Delicious to about one third in 2012. Gala apples are one of the cultivars that have gained ground in popularity. In this article, the authors compare how internal fruit qualities affect consumers' willingness to pay for apples and whether these effects differ across these two cultivars. Consumers are willing to pay more for firmness for both cultivars, with a larger effect for Red Delicious. Using consumer assessments of sweetness acceptability, consumers are willing to pay a positive amount for both cultivars, but the effect of sweetness is higher for Gala apples. The only significant ethnicity variable is being Hispanic, which is associated with lower willingness to pay for Gala and higher willingness to pay for Red Delicious. One possible explanation is that the Hispanic consumers may have stronger food traditions associated with 2 Appearance is extremely important in the immediate decision of whether to purchase. Yue, Alfnes, and Jensen (2009) find that cosmetic damage has a significant impact on both organic and conventional apples. Loureiro, McCluskey, and Mittelhammer (2001) find that appearance has a highly significant effect on willingness to for ecolabeled apples.3 If one considers appearance as an information signal of quality, then it could influence taste evaluations. Wansink and Park (2002) find that soy labels negatively bias taste perceptions and attitudes towards foods only thought to contain soy, but without actual soy. In this case, appearance could have a positive effect on taste perceptions. 4 Other aspects of quality such as color were not evaluated in this test. Although important, in this test situation color was not readily observable because the apples were served to the survey takers already sliced on a plate limiting the impact of visual perception of the skin of the apple.

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Endoscopic surgery combined with a piezoelectric device has obvious advantage of minimizing surgical injury and providing excellent visibility of surgical field when removing long-term foreign bodies in maxillary sinus. It is efficient and protects the residual alveolar bone.

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In order to avoid malicious competition and select high quality crowd workers to improve the utility of crowdsourcing system, this paper proposes an incentive mechanism based on the combination of reverse auction and multi-attribute auction in mobile crowdsourcing. The proposed online incentive mechanism includes two algorithms. One is the crowd worker selection algorithm based on multi-attribute reverse auction that adopts dynamic threshold to make an online decision for whether accept a crowd worker according to its attributes. Another is the payment determination algorithm which determines payment for a crowd worker based on its reputation and quality of sensing data, that is, a crowd worker can get payment equal to the bidding price before performing task only if his reputation reaches good reputation threshold, otherwise he will get payment based on his data sensing quality. We prove that our proposed online incentive mechanism has the properties of computational efficiency, individual rationality, budget-balance, truthfulness and honesty. Through simulations, the efficiency of our proposed online incentive mechanism is verified which can improve the efficiency, adaptability and trust degree of the mobile crowdsourcing system.