This study examined the relationships between university students' Internet use and students' academic performance, interpersonal relationships, psychosocial adjustment, and self-evaluation. The study was based on data drawn from a national survey of college students in Taiwan. A stratified sample of 49,609 students (2005-2006 academic year juniors) was randomly selected from 156 universities (174,277 students). Students completed a questionnaire online. Heavy Internet users and nonheavy Internet users differed significantly on a number of dimensions. Nonheavy users had better relationships with administrative staff, academic grades, and learning satisfaction than heavy Internet users. Heavy users were more likely than non-heavy Internet users to be depressed, physically ill, lonely, and introverted.

View related articles View Crossmark data Citing articles: 10 View citing articles EnvironmEntal Education rEsEarch

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway regulates cell proliferation, differentiation, and migration, along with angiogenesis and metabolism. Additionally, it could mediate skin development and homeostasis. There is much evidence to suggest that dysregulation of PI3K/Akt pathway is frequently associated with several human cutaneous malignancies like malignant melanoma (MM), basal cell carcinoma (BCC), and cutaneous squamous cell carcinoma (SCC), as well as their poor outcomes. Nevertheless, emerging roles of PI3K/Akt pathway cascade in a group of common non-malignant skin disorders including acne and psoriasis, among others, have been recognized. The enhanced understanding of dysfunction of PI3K/Akt pathway in patients with these non-malignant disorders has offered a solid foundation for the progress of updated therapeutic targets. This article reviews the latest advances in the roles of PI3K/Akt pathway and their targets in the skin homeostasis and progression of a wide range of non-malignant skin disorders and describes the current progress in preclinical and clinical researches on the involvement of PI3K/Akt pathway targeted therapies.

No abstract